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Diabetes Discussion
Type 1.5/LADA Diabetes
Is LADA hereditary?
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<blockquote data-quote="phoenix" data-source="post: 963505" data-attributes="member: 12578"><p>Heritability is a minefield, although it is known that T2 is very heritable and lots of research has been done into the genetics of it, the heritability estimates vary widely from 20-80% heritability</p><p></p><p>It's even more the case for LADA where there has been almost no research.</p><p>The risk for T1 is thought to be the result of certain predisposing genes yet the heritability isn't nearly as high as for T2.( further increased risk if you have a sibling with T1 though )</p><p>For LADA the info I could find seems to suggest that people with a family history of any sort of diabetes have an increased risk that is higher than that for T1 and slightly less than for T2 (though the prevalence of LADA is low so when you are thinking about increased risk that is a very important factor to be taken into account, the prevalence of T2 is much higher)</p><p></p><p>Interestingly, people with LADA who have higher levels of antibodies are less likely to have a family history of diabetes. Those with lower levels of antibodies are more likely to have a family history of diabetes.</p><p>" A tentative explanation could be that less autoimmune activity is required to cause LADA in individuals with genetic susceptibility to diabetes (i.e., genetic susceptibility of a kind that is unrelated to autoimmunity)" <a href="http://care.diabetesjournals.org/content/30/12/3040.full.pdf" target="_blank">http://care.diabetesjournals.org/content/30/12/3040.full.pdf</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 963505, member: 12578"] Heritability is a minefield, although it is known that T2 is very heritable and lots of research has been done into the genetics of it, the heritability estimates vary widely from 20-80% heritability It's even more the case for LADA where there has been almost no research. The risk for T1 is thought to be the result of certain predisposing genes yet the heritability isn't nearly as high as for T2.( further increased risk if you have a sibling with T1 though ) For LADA the info I could find seems to suggest that people with a family history of any sort of diabetes have an increased risk that is higher than that for T1 and slightly less than for T2 (though the prevalence of LADA is low so when you are thinking about increased risk that is a very important factor to be taken into account, the prevalence of T2 is much higher) Interestingly, people with LADA who have higher levels of antibodies are less likely to have a family history of diabetes. Those with lower levels of antibodies are more likely to have a family history of diabetes. " A tentative explanation could be that less autoimmune activity is required to cause LADA in individuals with genetic susceptibility to diabetes (i.e., genetic susceptibility of a kind that is unrelated to autoimmunity)" [URL]http://care.diabetesjournals.org/content/30/12/3040.full.pdf[/URL] [/QUOTE]
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Type 1.5/LADA Diabetes
Is LADA hereditary?
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