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<blockquote data-quote="AMBrennan" data-source="post: 226151" data-attributes="member: 37697"><p>Not necessarily - it's quite possible that they looked at a regression deaths vs HbA1C, or GLM risk vs control. I <strong>haven't read</strong> the relevant literature so I can't claim that they did this properly, but you can't claim that they didn't.</p><p>For example, the recent ACCORD study high risk CVD patients did this very well - they followed two groups of patients (intensive control vs standard) and looked at the risk of CVD incidents (too bad they got the wrong result and had to stop the study early). </p><p></p><p>Of course, the long term risk is difficult if not impossible to estimate -but keep in mind that diabetes complications are due to high glucose levels damaging blood vessels; current treatment targets are < 7.5% which is much higher than the healthy population. If you are taking insulin the you need to maintain much higher BG to avoid hypos (BG > 6 mmol/l if you are driving, fasting > 5.5 mmol/l according to my DSN when normal fasting is 4-6)</p><p>It is not inconceivable that this might lead to an increased risk of complications, including CVD. Then again, theoretical biochemistry tends to work better in a textbook than in practise (cf antioxidants)</p></blockquote><p></p>
[QUOTE="AMBrennan, post: 226151, member: 37697"] Not necessarily - it's quite possible that they looked at a regression deaths vs HbA1C, or GLM risk vs control. I [b]haven't read[/b] the relevant literature so I can't claim that they did this properly, but you can't claim that they didn't. For example, the recent ACCORD study high risk CVD patients did this very well - they followed two groups of patients (intensive control vs standard) and looked at the risk of CVD incidents (too bad they got the wrong result and had to stop the study early). Of course, the long term risk is difficult if not impossible to estimate -but keep in mind that diabetes complications are due to high glucose levels damaging blood vessels; current treatment targets are < 7.5% which is much higher than the healthy population. If you are taking insulin the you need to maintain much higher BG to avoid hypos (BG > 6 mmol/l if you are driving, fasting > 5.5 mmol/l according to my DSN when normal fasting is 4-6) It is not inconceivable that this might lead to an increased risk of complications, including CVD. Then again, theoretical biochemistry tends to work better in a textbook than in practise (cf antioxidants) [/QUOTE]
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