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<blockquote data-quote="semiphonic" data-source="post: 574188" data-attributes="member: 97458"><p>I just found this on patient.co.uk -</p><p></p><p>"*The reputation of the biguanide <a href="http://www.patient.co.uk/search.asp?searchterm=METFORMIN&collections=PPsearch" target="_blank">metformin</a> for causing lactic acidosis may be overstated, and largely based on experience with its more toxic predecessor phenformin. It can cause lactic acidosis in overdose, or if continued in severely ill diabetics who become <a href="http://www.patient.co.uk/search.asp?searchterm=DEHYDRATED&collections=PPsearch" target="_blank">dehydrated</a>, but seems to be well tolerated on the whole, with many of the current cautions for conditions such as heart failure probably being overzealous and denying a safe and useful therapy to many patients.[<a href="http://www.patient.co.uk/doctor/Lactic-Acidosis.htm#ref-5" target="_blank">5</a>] A Cochrane systematic review found no evidence of an association with lactic acidosis or hyperlactataemia in study-based use.[<a href="http://www.patient.co.uk/doctor/Lactic-Acidosis.htm#ref-6" target="_blank">6</a>]"</p><p></p><p><span style="font-size: 12px">I don't have any issues with drinking alcohol, although I do find I get drunk quicker than I used to, so I choose to be a bit more careful with my intake. Also I don't seem to get hangovers anymore which obviously is a bonus!</span></p></blockquote><p></p>
[QUOTE="semiphonic, post: 574188, member: 97458"] I just found this on patient.co.uk - "*The reputation of the biguanide [URL='http://www.patient.co.uk/search.asp?searchterm=METFORMIN&collections=PPsearch']metformin[/URL] for causing lactic acidosis may be overstated, and largely based on experience with its more toxic predecessor phenformin. It can cause lactic acidosis in overdose, or if continued in severely ill diabetics who become [URL='http://www.patient.co.uk/search.asp?searchterm=DEHYDRATED&collections=PPsearch']dehydrated[/URL], but seems to be well tolerated on the whole, with many of the current cautions for conditions such as heart failure probably being overzealous and denying a safe and useful therapy to many patients.[[URL='http://www.patient.co.uk/doctor/Lactic-Acidosis.htm#ref-5']5[/URL]] A Cochrane systematic review found no evidence of an association with lactic acidosis or hyperlactataemia in study-based use.[[URL='http://www.patient.co.uk/doctor/Lactic-Acidosis.htm#ref-6']6[/URL]]" [SIZE=3]I don't have any issues with drinking alcohol, although I do find I get drunk quicker than I used to, so I choose to be a bit more careful with my intake. Also I don't seem to get hangovers anymore which obviously is a bonus![/SIZE] [/QUOTE]
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