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<blockquote data-quote="SimonCrox" data-source="post: 1614557" data-attributes="member: 388174"><p>Sorry to hear about the mesothelioma, but good to hear that it is static.</p><p>I would agree with you about the metformin.</p><p>Starting from a different direction (sorry), if one is on half maximal dose of one agent and not controlled, adding a different agent is more effective with less side effects than doubling the first agent. Metformin is more likely to cause tummy upsets than sitagliptin (although both can). So continuing the sitagliptin and decreasing the metformin might well reduce the tummy upset and leave your diabetic control similar to what it is.</p><p>I would just check with your doctors that your kidney function (eGFR) is OK for your doses of metformin and sitagliptin: your eGFR might have decreased with time (it does with everyone), so that your kidneys have diffiuclty getting rid of metformin or sitagliptin, increasing the risk of side effects. I presume that they use the eGFR in France.</p><p>Best wishes</p></blockquote><p></p>
[QUOTE="SimonCrox, post: 1614557, member: 388174"] Sorry to hear about the mesothelioma, but good to hear that it is static. I would agree with you about the metformin. Starting from a different direction (sorry), if one is on half maximal dose of one agent and not controlled, adding a different agent is more effective with less side effects than doubling the first agent. Metformin is more likely to cause tummy upsets than sitagliptin (although both can). So continuing the sitagliptin and decreasing the metformin might well reduce the tummy upset and leave your diabetic control similar to what it is. I would just check with your doctors that your kidney function (eGFR) is OK for your doses of metformin and sitagliptin: your eGFR might have decreased with time (it does with everyone), so that your kidneys have diffiuclty getting rid of metformin or sitagliptin, increasing the risk of side effects. I presume that they use the eGFR in France. Best wishes [/QUOTE]
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