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"new" link between diet and atherosclerosis
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<blockquote data-quote="Cowboyjim" data-source="post: 317272" data-attributes="member: 23128"><p><a href="http://www.sciencedaily.com/releases/2012/10/121009131511.htm" target="_blank">http://www.sciencedaily.com/releases/2012/10/121009131511.htm</a></p><p></p><p>Columbia University Medical Center (CUMC) researchers have found that a diet high in saturated fat raises levels of endothelial lipase (EL), an enzyme associated with the development of atherosclerosis, and, conversely, that a diet high in omega-3 polyunsaturated fat lowers levels of this enzyme. </p><p></p><p>The findings establish a "new" link between diet and atherosclerosis and suggest a novel way to prevent cardiovascular heart disease. In addition, the research may help to explain why the type 2 diabetes drug rosiglitazone (<strong>Avandia</strong>) has been linked to heart problems.</p><p></p><p>these results need to be confirmed in human studies," said Dr. Deckelbaum. "The findings might also explain some of the cardiovascular benefits that have been attributed to omega-3 fatty acids."</p><p></p><p>"So we hypothesized that if rosiglitazone activates ppar-gamma, it might also activate EL, which would explain its effects on the heart."</p><p></p><p>In a similar vein (groan)</p><p><a href="http://www.sciencedaily.com/releases/2012/10/121009112129.htm" target="_blank">http://www.sciencedaily.com/releases/2012/10/121009112129.htm</a></p><p>Using these mice to study how disruption of PPAR-gamma leads to high blood pressure, the researchers uncovered a new biological pathway (called the Cullin-3 pathway) in blood vessels, which may be the key to the blood pressure-lowering effects of TZD drugs.</p><p>thiazolidinedione drugs (also known as TZDs), which are used to treat type 2 diabetes. These are highly effective in controlling blood glucose levels and have an added benefit of lowering blood pressure in some patients. However, TZDs cause unrelated but potentially severe side effects in some patients</p></blockquote><p></p>
[QUOTE="Cowboyjim, post: 317272, member: 23128"] [url]http://www.sciencedaily.com/releases/2012/10/121009131511.htm[/url] Columbia University Medical Center (CUMC) researchers have found that a diet high in saturated fat raises levels of endothelial lipase (EL), an enzyme associated with the development of atherosclerosis, and, conversely, that a diet high in omega-3 polyunsaturated fat lowers levels of this enzyme. The findings establish a "new" link between diet and atherosclerosis and suggest a novel way to prevent cardiovascular heart disease. In addition, the research may help to explain why the type 2 diabetes drug rosiglitazone ([b]Avandia[/b]) has been linked to heart problems. these results need to be confirmed in human studies," said Dr. Deckelbaum. "The findings might also explain some of the cardiovascular benefits that have been attributed to omega-3 fatty acids." "So we hypothesized that if rosiglitazone activates ppar-gamma, it might also activate EL, which would explain its effects on the heart." In a similar vein (groan) [url]http://www.sciencedaily.com/releases/2012/10/121009112129.htm[/url] Using these mice to study how disruption of PPAR-gamma leads to high blood pressure, the researchers uncovered a new biological pathway (called the Cullin-3 pathway) in blood vessels, which may be the key to the blood pressure-lowering effects of TZD drugs. thiazolidinedione drugs (also known as TZDs), which are used to treat type 2 diabetes. These are highly effective in controlling blood glucose levels and have an added benefit of lowering blood pressure in some patients. However, TZDs cause unrelated but potentially severe side effects in some patients [/QUOTE]
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