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<blockquote data-quote="Indy51" data-source="post: 1619120" data-attributes="member: 48386"><p>It sounds like your first phase insulin response is compromised. I have the same thing, though I can tolerate more carbs since I started time restricted eating than I could when first diagnosed. One of my genetic polymorphisms is described below:</p><p></p><p><em>"rs13266634(C;C) - increased risk for type-2 diabetes - rs13266634 is a SNP in the zinc transporter protein member 8 SLC30A8 gene that has primarily been associated with type-2 diabetes in several studies. This SNP is also known as the Arg325Trp or R325W variant; the (C) allele encodes the arginine (R), and the (T) allele encodes the tryptophan (W). significantly associated p = 0.0073; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls The major alleles of the SLC30A8 SNP rs13266634 and the HHEX SNP rs7923837 <strong>associate with reduced insulin secretion, but not with insulin resistance. 46% of European non-diabetic offspring of type-2 diabetes patients are rs13266634(C;C) homozygotes; they are diabetes-prone and characterised by a 19% decrease in first-phase insulin release following an intravenous glucose load.</strong>"</em></p><p></p><p>Seems to be a fairly common variant among Europeans. Maybe you have the same?</p><p></p><p>Jenny Ruhl's description of first phase insulin release:</p><p><em><span style="font-size: 15px"></span></em></p><p><em><span style="font-size: 15px"><strong>"First Phase Insulin Release</strong></span></em></p><p><em>When a health person starts to eat a meal, the beta-cells kick into high gear. Their stored insulin is released immediately. Then, if the blood sugar concentration rises over 100 mg/dl, (5.5 mmol/L) the beta-cells start secreting more insulin into the blood stream. This early release of stored insulin after a meal is called "First Phase Insulin Release." In a healthy person it keeps the blood sugar from rising very high because it is available to meet most of the glucose that comes from the digestion of the current meal.</em></p><p><em>The amount of insulin secreted in the first phase response to a meal is usually determined by the amount of glucose encountered in the previous meal. In a healthy person, this first phase response peaks a few minutes after you've started your a meal. The blood sugar rise caused by the meal peaks about half an hour after you start eating."</em></p></blockquote><p></p>
[QUOTE="Indy51, post: 1619120, member: 48386"] It sounds like your first phase insulin response is compromised. I have the same thing, though I can tolerate more carbs since I started time restricted eating than I could when first diagnosed. One of my genetic polymorphisms is described below: [I]"rs13266634(C;C) - increased risk for type-2 diabetes - rs13266634 is a SNP in the zinc transporter protein member 8 SLC30A8 gene that has primarily been associated with type-2 diabetes in several studies. This SNP is also known as the Arg325Trp or R325W variant; the (C) allele encodes the arginine (R), and the (T) allele encodes the tryptophan (W). significantly associated p = 0.0073; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls The major alleles of the SLC30A8 SNP rs13266634 and the HHEX SNP rs7923837 [B]associate with reduced insulin secretion, but not with insulin resistance. 46% of European non-diabetic offspring of type-2 diabetes patients are rs13266634(C;C) homozygotes; they are diabetes-prone and characterised by a 19% decrease in first-phase insulin release following an intravenous glucose load.[/B]"[/I] Seems to be a fairly common variant among Europeans. Maybe you have the same? Jenny Ruhl's description of first phase insulin release: [I][SIZE=4][B][/B] [B]"First Phase Insulin Release[/B][/SIZE] When a health person starts to eat a meal, the beta-cells kick into high gear. Their stored insulin is released immediately. Then, if the blood sugar concentration rises over 100 mg/dl, (5.5 mmol/L) the beta-cells start secreting more insulin into the blood stream. This early release of stored insulin after a meal is called "First Phase Insulin Release." In a healthy person it keeps the blood sugar from rising very high because it is available to meet most of the glucose that comes from the digestion of the current meal. The amount of insulin secreted in the first phase response to a meal is usually determined by the amount of glucose encountered in the previous meal. In a healthy person, this first phase response peaks a few minutes after you've started your a meal. The blood sugar rise caused by the meal peaks about half an hour after you start eating."[/I] [/QUOTE]
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