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<blockquote data-quote="Brunneria" data-source="post: 958924" data-attributes="member: 41816"><p>My gut reaction on the Metformin question is that timing is unlikely to make any difference to the performance of the Metformin - so may be worth trying and see if it changes your other issues. Can't comment on the Diamicron at all, I am afraid.</p><p></p><p>The reason I say that about the Met is because it is a drug thats effect builds slowly, and reduces slowly. The full benefit not being felt for 2-3 weeks of consistent use. So swapping time of day of tablet taking isn't going to have much effect. Although they do advise taking it with food, since that is gentler on the tum.</p><p></p><p>Metformin's weight loss reputation is because of two things - one being it is claimed to be an appetite suppressant, the other is that is drops the blood glucose level by a little (we are only talking about 1-2 mmol/l, so it isn't and earth shattering drop, which many people don't realise!), which in turn will reduce insulin resistance by a little. And where there is less insulin resistance, there is a chance of weigh loss and less liklihood of weight gain.</p><p></p><p>Hope that helps.</p></blockquote><p></p>
[QUOTE="Brunneria, post: 958924, member: 41816"] My gut reaction on the Metformin question is that timing is unlikely to make any difference to the performance of the Metformin - so may be worth trying and see if it changes your other issues. Can't comment on the Diamicron at all, I am afraid. The reason I say that about the Met is because it is a drug thats effect builds slowly, and reduces slowly. The full benefit not being felt for 2-3 weeks of consistent use. So swapping time of day of tablet taking isn't going to have much effect. Although they do advise taking it with food, since that is gentler on the tum. Metformin's weight loss reputation is because of two things - one being it is claimed to be an appetite suppressant, the other is that is drops the blood glucose level by a little (we are only talking about 1-2 mmol/l, so it isn't and earth shattering drop, which many people don't realise!), which in turn will reduce insulin resistance by a little. And where there is less insulin resistance, there is a chance of weigh loss and less liklihood of weight gain. Hope that helps. [/QUOTE]
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