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stop diabetes two stigma and find a cure instead of blaming us for being sick
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<blockquote data-quote="phoenix" data-source="post: 674209" data-attributes="member: 12578"><p>I don't think blame and stigmatisation of people helps one little bit and is totally wrong.</p><p></p><p>.However blaming it on genes can't be the whole story either. There are obviously some families that may have rare genetic mutations which affect their family . People with MODY have very rare variants that mean each child from a carrier parent has a 50% chance of developing diabetes. I'm sure that there will be similar rare 'familial' genes that 'cause' some individuals 'type 2' diabetes.</p><p></p><p>The incidence of T2 though has increased dramatically and because DNA changes extremely slowly, genetic change can't account for the big increase seen in recent years.</p><p>. .</p><p>The simplest answer is often the most likely.</p><p></p><p>Our 'food' environment has undergone rapid change, just look at a photo of the high street now and 30 years ago, The population in the UK and in many other parts of Europe have along with these changes become more overweight. It includes those who would not be classified as overweight, (slight edit for grammar) It's a general shift upwards.</p><p>There are some excellent slides of graphs and pictures of people in the street presented in Professor Taylors recent lecture which demonstrate this very clearly. He suggests that it this shift of weight upwards has pushed people past the threshold at which they as an individual are likely to become diabetic</p><p></p><p>I think this ties in with a genetic study from EPIC (this is a very large European research collaboration) They looked at over 16000 middle aged people who were not diabetic at the start of the study .</p><p>They sequenced DNA to look for 49 SNPs (genetic variations) that have been found to be most associated with T2 in European populations They then followed them up for up to 10 years.</p><p></p><p>They found theyounger people with a high number of these related SNPs were at a slightly higher risk at all weights . For the most part though what made the difference was weight (and waist measurement)</p><p> If you had lots of the diabetes associated SNPs but you remained thin ie had a BMI under 25 then you had only a small risk of developing T2. In fact even with lots of 'diabetes SNPs' you had a lower risk of developing T2 than someone who had only few diabetes related SNPs but was very overweight.</p><p>(graphs 1-4 left to right; increasing number of diabetes SNPs , red line BMI less than 25, blue BMI 25 to 30 , black over 30 <a href="http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001647" target="_blank">http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001647</a></p><p></p><p>[ATTACH]8122[/ATTACH]</p><p></p><p>So far fewer people would be likely to develop T2 when it was the norm for people to have a BMI of less than 25. People had the same genes and the same risks . What has changed is an environment where ready prepared, cheap calories are easily available all day, everyday . The problem is how to reverse/change the environment.</p><p></p><p>.</p></blockquote><p></p>
[QUOTE="phoenix, post: 674209, member: 12578"] I don't think blame and stigmatisation of people helps one little bit and is totally wrong. .However blaming it on genes can't be the whole story either. There are obviously some families that may have rare genetic mutations which affect their family . People with MODY have very rare variants that mean each child from a carrier parent has a 50% chance of developing diabetes. I'm sure that there will be similar rare 'familial' genes that 'cause' some individuals 'type 2' diabetes. The incidence of T2 though has increased dramatically and because DNA changes extremely slowly, genetic change can't account for the big increase seen in recent years. . . The simplest answer is often the most likely. Our 'food' environment has undergone rapid change, just look at a photo of the high street now and 30 years ago, The population in the UK and in many other parts of Europe have along with these changes become more overweight. It includes those who would not be classified as overweight, (slight edit for grammar) It's a general shift upwards. There are some excellent slides of graphs and pictures of people in the street presented in Professor Taylors recent lecture which demonstrate this very clearly. He suggests that it this shift of weight upwards has pushed people past the threshold at which they as an individual are likely to become diabetic I think this ties in with a genetic study from EPIC (this is a very large European research collaboration) They looked at over 16000 middle aged people who were not diabetic at the start of the study . They sequenced DNA to look for 49 SNPs (genetic variations) that have been found to be most associated with T2 in European populations They then followed them up for up to 10 years. They found theyounger people with a high number of these related SNPs were at a slightly higher risk at all weights . For the most part though what made the difference was weight (and waist measurement) If you had lots of the diabetes associated SNPs but you remained thin ie had a BMI under 25 then you had only a small risk of developing T2. In fact even with lots of 'diabetes SNPs' you had a lower risk of developing T2 than someone who had only few diabetes related SNPs but was very overweight. (graphs 1-4 left to right; increasing number of diabetes SNPs , red line BMI less than 25, blue BMI 25 to 30 , black over 30 [URL='http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001647']http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001647[/URL] [ATTACH]8122[/ATTACH] So far fewer people would be likely to develop T2 when it was the norm for people to have a BMI of less than 25. People had the same genes and the same risks . What has changed is an environment where ready prepared, cheap calories are easily available all day, everyday . The problem is how to reverse/change the environment. . [/QUOTE]
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