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<blockquote data-quote="phoenix" data-source="post: 203949" data-attributes="member: 12578"><p>I think that the headlines are a bit misleading. The researchers were well aware from the start that both too much fat (lipotoxicity) too much glucose (glucotoxicity) may cause cell death. They are both implicated in insulin resistance and beta cell death.</p><p>They showed that in those hostile environments (fatty acids/glucose) then indeed the cell died, They also found a mechanism for this. This was the activation of these particular RNAs. They also found that if they disabled the RNAs the cells didn't die even when in the hostile environment.</p><p>Pratically as the doctor says controlling diet ie both fat and sugar may help reduce the conditions for cell death but if this doesnt work then this knowledge could lead to a treatment</p><p></p><p>The fatty acid they used to cause the cell death in the experiments was palmitic. This is a saturated fat, found in palm oil, coconut oil, meat and dairy produce. However eating palmitc acid doesn't <strong>necessarily</strong> lead to a lot of it in the body . We eat fats but they are then broken up before they are absorbed, later other fats are synthesized. Palmitic acid is the first to be synthesized, it is also made when new fat is created from <strong>excess</strong> carbohydrate, though this is actually a minor pathway in humans (google Hellerstein de novolipogenesis)</p><p>This is a good primer on fat breakdown/ absorption/storage</p><p></p><p><a href="http://science.howstuffworks.com/environmental/life/human-biology/fat-cell1.htm" target="_blank">http://science.howstuffworks.com/enviro ... -cell1.htm</a></p><p></p><p> This is the conclusion by K Frayn of a brief review on the state of knowledge today (2010)</p><p></p><p>(linoleic acid is a polyunsaturated fat, 17 is margaric acid a very minor fatty acid and is found in dairy and in lamb and beef.)</p><p>He summarises his views in a seesaw diagram showing those dietary macronutrients and nutrients that may be implicated with insulin sensitiviy and those that may be implicated in resistance.</p><p>Senstivity : polyunsaturated, monounsaturated fats. fibre dairy products? VIt D,chromium, magnesium, zinc,</p><p>resistance : saturated fats (non dairy?) omega 3 polyunsaturated , simple sugars (fructose?)</p><p></p><p>(interesting about the omega 3, Fray actually says it was it was a weak association and : <em>T , the undoubted other health benefits of fish or fish-oil intake in non-diabetic and diabetic [20, 21] people almost certainly outweigh this small effect</em></p><p><a href="http://www.springerlink.com/content/441413412608848u/fulltext.html" target="_blank">http://www.springerlink.com/content/441 ... ltext.html</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 203949, member: 12578"] I think that the headlines are a bit misleading. The researchers were well aware from the start that both too much fat (lipotoxicity) too much glucose (glucotoxicity) may cause cell death. They are both implicated in insulin resistance and beta cell death. They showed that in those hostile environments (fatty acids/glucose) then indeed the cell died, They also found a mechanism for this. This was the activation of these particular RNAs. They also found that if they disabled the RNAs the cells didn't die even when in the hostile environment. Pratically as the doctor says controlling diet ie both fat and sugar may help reduce the conditions for cell death but if this doesnt work then this knowledge could lead to a treatment The fatty acid they used to cause the cell death in the experiments was palmitic. This is a saturated fat, found in palm oil, coconut oil, meat and dairy produce. However eating palmitc acid doesn't [b]necessarily[/b] lead to a lot of it in the body . We eat fats but they are then broken up before they are absorbed, later other fats are synthesized. Palmitic acid is the first to be synthesized, it is also made when new fat is created from [b]excess[/b] carbohydrate, though this is actually a minor pathway in humans (google Hellerstein de novolipogenesis) This is a good primer on fat breakdown/ absorption/storage [url=http://science.howstuffworks.com/environmental/life/human-biology/fat-cell1.htm]http://science.howstuffworks.com/enviro ... -cell1.htm[/url] This is the conclusion by K Frayn of a brief review on the state of knowledge today (2010) (linoleic acid is a polyunsaturated fat, 17 is margaric acid a very minor fatty acid and is found in dairy and in lamb and beef.) He summarises his views in a seesaw diagram showing those dietary macronutrients and nutrients that may be implicated with insulin sensitiviy and those that may be implicated in resistance. Senstivity : polyunsaturated, monounsaturated fats. fibre dairy products? VIt D,chromium, magnesium, zinc, resistance : saturated fats (non dairy?) omega 3 polyunsaturated , simple sugars (fructose?) (interesting about the omega 3, Fray actually says it was it was a weak association and : [i]T , the undoubted other health benefits of fish or fish-oil intake in non-diabetic and diabetic [20, 21] people almost certainly outweigh this small effect[/i] [url=http://www.springerlink.com/content/441413412608848u/fulltext.html]http://www.springerlink.com/content/441 ... ltext.html[/url] [/QUOTE]
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