Insulin Resistance where it is defined as a reduction in glucose transport into body cells is not properly part of type 2 diabetes but part of the metabolic syndrome which results in obesity. It is treated (as my diabetes specialist nurse says) by metformin which improves the action of insulin receptors and increases glucose transport. However glucose transport and the metabolic syndrome are fully curable so I no longer take metformin.
Most people with type 2 have hyperinsulinaemia (elevated insulin levels) even if they do not take insulin or insulin generators. The reason they have elevated blood glucose is not a failure of insulin production per se but a result of excess glucagon production by the islets in pancreatic alpha cells (this converts glycogen in the liver to glucose). In short your blood sugar is high because your body makes it that way. I call this phenonemon "Glucagon Admittance" which is the double inverse of "Insulin Resistance". Basically the two antagonists "insulin" and "glucagon" end up being produced at the same time as a result of the statistically random process of the poisoning of the modified electron transport chain reaction in pancreatic beta cells. This is the statistics of gaussian line broadening of the set point distribution function for both Insulin and the Glucagon Inhibitor produced by pancreatic beta cells.
Of course, you know what the poisoning agent is, don't you?
