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Vitamin D3 deficiency
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<blockquote data-quote="msmi1970" data-source="post: 958116" data-attributes="member: 129795"><p>my thoughts on this are too scattered...for more info, i would recommend youtube videos by Dr.Micheal Holick, Dr.Robert Heaney, Dr.Bruce Hollis & both Chris Masterjohn & Ivor Cummins have good material on this.</p><p></p><p>the first three chaps have studied this for a long time. Dr.Holick is a noted endocrinologist with more than 400 publications & numerous awards. He points out that there is a marked difference in recommendations for general populations & recommendations for therapeutic purposes.</p><p></p><p>Dr.Heaney gives a seriously fascinating talk on why RCT's are not well designed for vitamins/minerals etc</p><p></p><p>Critics argue that Vitamin D is fat soluble & therefore is stored in the body for long periods (half life of about 8 weeks in one study i think). But all the latest research shows that it's more complex than that. Only about 5% is converted into the active format used to manage calcium in the body. More importantly, it has been shown that almost all cells in the body have vitamin D receptors and that it is taken up directly by the cell. AFAIK, preliminary research has identified over 300 gene expressions that have been positively affected by the presence of vitamin D.</p><p></p><p>They also all touch on how general recommendations for populations are arrived at & why just doing enough to avoid rickets may not be optimal & that Vitamin D toxicity is rare.</p><p></p><p>Full disclosure, I have been 20,000 daily for a month. Taken with sufficient Vitamin K2 of course. Two clear things I have noticed are better looking teeth <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /> and my severely crooked toes have straightened up significantly. I am going to taper down to 5,000 daily as of tomorrow.</p></blockquote><p></p>
[QUOTE="msmi1970, post: 958116, member: 129795"] my thoughts on this are too scattered...for more info, i would recommend youtube videos by Dr.Micheal Holick, Dr.Robert Heaney, Dr.Bruce Hollis & both Chris Masterjohn & Ivor Cummins have good material on this. the first three chaps have studied this for a long time. Dr.Holick is a noted endocrinologist with more than 400 publications & numerous awards. He points out that there is a marked difference in recommendations for general populations & recommendations for therapeutic purposes. Dr.Heaney gives a seriously fascinating talk on why RCT's are not well designed for vitamins/minerals etc Critics argue that Vitamin D is fat soluble & therefore is stored in the body for long periods (half life of about 8 weeks in one study i think). But all the latest research shows that it's more complex than that. Only about 5% is converted into the active format used to manage calcium in the body. More importantly, it has been shown that almost all cells in the body have vitamin D receptors and that it is taken up directly by the cell. AFAIK, preliminary research has identified over 300 gene expressions that have been positively affected by the presence of vitamin D. They also all touch on how general recommendations for populations are arrived at & why just doing enough to avoid rickets may not be optimal & that Vitamin D toxicity is rare. Full disclosure, I have been 20,000 daily for a month. Taken with sufficient Vitamin K2 of course. Two clear things I have noticed are better looking teeth :) and my severely crooked toes have straightened up significantly. I am going to taper down to 5,000 daily as of tomorrow. [/QUOTE]
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