Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Diabetes Discussion
Type 2 Diabetes
What happens with Metformin if you don't eat, anything?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="LittleGreyCat" data-source="post: 1382875" data-attributes="member: 6467"><p>One thing I have noticed is that not all Metformin information in the drug packs seems to be the same.</p><p></p><p>For instance my current pack says not to take if your eGFR is below 45, 1,000 mg daily with eGFR between 45 and 60, and max dose of 3,000 mg per day otherwise. These tablets are from RelonChem.</p><p></p><p>However [USER=292414]@walnut_face[/USER] posted</p><p><a href="http://www.diabetes.co.uk/forum/threads/water-fasting-and-medication-e-g-metformin.115664/#post-1374572" target="_blank">http://www.diabetes.co.uk/forum/threads/water-fasting-and-medication-e-g-metformin.115664/#post-1374572</a></p><p>"Read the Patient Information Leaflet (PIL) My variety of metformin advises NOT to take them if following a VLC diet of <1000 cal".</p><p></p><p>My PIL doesn't seem to mention this at all.</p><p></p><p><a href="https://www.drugs.com/dosage/metformin.html" target="_blank">https://www.drugs.com/dosage/metformin.html</a> says "Maximum dose: 2550 mg daily".</p><p></p><p><a href="https://www.evidence.nhs.uk/formulary/bnf/current/6-endocrine-system/61-drugs-used-in-diabetes/612-antidiabetic-drugs/6122-biguanides/metformin-hydrochloride" target="_blank">https://www.evidence.nhs.uk/formulary/bnf/current/6-endocrine-system/61-drugs-used-in-diabetes/612-antidiabetic-drugs/6122-biguanides/metformin-hydrochloride</a></p><p>says "Diabetes mellitus, ADULT and CHILD over 10 years initially 500 mg with breakfast for at least 1 week then 500 mg with breakfast and evening meal for at least 1 week then 500 mg with breakfast, lunch and evening meal; usual max. 2 g daily in divided doses" but also, tellingly, "</p><p><span style="font-size: 12px"><strong>Note</strong></span></p><p><strong><em><u>Metformin doses in the BNF may differ from those in the product literature</u></em></strong></p><p>"</p><p>Oh, and "</p><p><span style="font-size: 12px"><strong>Lactic acidosis</strong></span></p><p>Use with caution in renal impairment—increased risk of lactic acidosis; avoid in significant renal impairment. NICE<a href="https://www.evidence.nhs.uk/formulary/bnf/current/6-endocrine-system/61-drugs-used-in-diabetes/612-antidiabetic-drugs/6122-biguanides/metformin-hydrochloride#bnf-fn_1" target="_blank">(1)</a> recommends that the dose should be reviewed if eGFR less than 45 mL/minute/1.73 m2 and to avoid if eGFR less than 30 mL/minute/1.73 m2. Withdraw or interrupt treatment in those at risk of tissue hypoxia or sudden deterioration in renal function, such as those with dehydration, severe infection, shock, sepsis, acute heart failure, respiratory failure or hepatic impairment, or those who have recently had a myocardial infarction</p><p>"</p><p></p><p>So which information source should you rely on??????</p><p></p><p>Edit:</p><p><a href="http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1469768893814.pdf" target="_blank">http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1469768893814.pdf</a></p><p>should be the generic PIL and that has the 3,000 mg maximum limit.</p></blockquote><p></p>
[QUOTE="LittleGreyCat, post: 1382875, member: 6467"] One thing I have noticed is that not all Metformin information in the drug packs seems to be the same. For instance my current pack says not to take if your eGFR is below 45, 1,000 mg daily with eGFR between 45 and 60, and max dose of 3,000 mg per day otherwise. These tablets are from RelonChem. However [USER=292414]@walnut_face[/USER] posted [URL]http://www.diabetes.co.uk/forum/threads/water-fasting-and-medication-e-g-metformin.115664/#post-1374572[/URL] "Read the Patient Information Leaflet (PIL) My variety of metformin advises NOT to take them if following a VLC diet of <1000 cal". My PIL doesn't seem to mention this at all. [URL]https://www.drugs.com/dosage/metformin.html[/URL] says "Maximum dose: 2550 mg daily". [URL]https://www.evidence.nhs.uk/formulary/bnf/current/6-endocrine-system/61-drugs-used-in-diabetes/612-antidiabetic-drugs/6122-biguanides/metformin-hydrochloride[/URL] says "Diabetes mellitus, ADULT and CHILD over 10 years initially 500 mg with breakfast for at least 1 week then 500 mg with breakfast and evening meal for at least 1 week then 500 mg with breakfast, lunch and evening meal; usual max. 2 g daily in divided doses" but also, tellingly, " [SIZE=3][B]Note[/B][/SIZE] [B][I][U]Metformin doses in the BNF may differ from those in the product literature[/U][/I][/B] " Oh, and " [SIZE=3][B]Lactic acidosis[/B][/SIZE] Use with caution in renal impairment—increased risk of lactic acidosis; avoid in significant renal impairment. NICE[URL='https://www.evidence.nhs.uk/formulary/bnf/current/6-endocrine-system/61-drugs-used-in-diabetes/612-antidiabetic-drugs/6122-biguanides/metformin-hydrochloride#bnf-fn_1'](1)[/URL] recommends that the dose should be reviewed if eGFR less than 45 mL/minute/1.73 m2 and to avoid if eGFR less than 30 mL/minute/1.73 m2. Withdraw or interrupt treatment in those at risk of tissue hypoxia or sudden deterioration in renal function, such as those with dehydration, severe infection, shock, sepsis, acute heart failure, respiratory failure or hepatic impairment, or those who have recently had a myocardial infarction " So which information source should you rely on?????? Edit: [URL]http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1469768893814.pdf[/URL] should be the generic PIL and that has the 3,000 mg maximum limit. [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Type 2 Diabetes
What happens with Metformin if you don't eat, anything?
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…