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Why do blood sugar levels rise after some sport?
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<blockquote data-quote="mc-" data-source="post: 189539" data-attributes="member: 33949"><p>Sometimes if insulin levels are high before you exercise, they can stay high if you're not working at a heart rate level high enough to be burning up the blood/muscle glucose that's circulating</p><p></p><p>The lactate/insulin connection is interesting: lactate is used as a substrate for energy - so it's a good thing. We tap into it generally when we're working at the threshold of aerobic (fat burning/oxygen use) and anaerobic (doesn't need oxygen to burn, so phosphate, glucose and lactate metabolism go in here).</p><p></p><p>A paper in 2002 suggested that lactate was a big insulin resistance inducer - so no getting glucose into the cell with lactate around (AJP-Endo Articles in PresS. Published on April 30, 2002 as DOI 10.1152/ajpendo.00557.2001) But more recently, work shows that lactate suppresses glycolosis (conversion of glucose into pyruvate for ATP - in short conversion of glucose into energy) not insulin uptake. </p><p></p><p>THis makes sense to me: one does lactate threshold training in endurance in order to be "glycogen sparing" - to be able to up the aerobic threshold (ability to rely on fat as fuel before cracking into the faster used up sugar supplies). Intriguingly, lactate is a by-product of anaerobic fuel burning that feeds back into the aerobic system for fuel. The better the aerobic system can utilize lactate the more effective and efficient and usually powerful it is.</p><p></p><p></p><p> So, a paper in 2008 (EFFECT OF LACTATE ON INSULIN ACTION IN RATS) also looking at rodents showed that simultaneous exposure of insulin and lactate in the rats resulted in way more glucose uptake (which would suggest improved insulin sensitivity). That's a good thing.</p><p></p><p>Related - a recent paper (<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946576/?tool=pubmed" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed</a>) shows that working at lactate thresholod can be a good way to improve insulin senstivity. BUT also low instensity aerobic work reduced IGF (insulin like growth factor 1) and increased circulating IGFbp (igf binding proteins).</p><p></p><p>SO - bottom line seems to be that, if muscles are working hard enough to say i'm running out of fuel; stick more glucose into me please, then glucose levels go up but genearlly speaking that elevation is going to come down after the demand has been satisfied unless the levels were a bit oversaturated to begin with. </p><p></p><p>Lactate is a good thing that should not interfere with insulin but may reduce the need for glycolosis - thus that extra load may be floating around in the blood stream. And of course if you had any kind of recovery drink during or after the bout that will add too.</p><p></p><p>Does that help? clear as mud?</p><p></p><p>mc</p></blockquote><p></p>
[QUOTE="mc-, post: 189539, member: 33949"] Sometimes if insulin levels are high before you exercise, they can stay high if you're not working at a heart rate level high enough to be burning up the blood/muscle glucose that's circulating The lactate/insulin connection is interesting: lactate is used as a substrate for energy - so it's a good thing. We tap into it generally when we're working at the threshold of aerobic (fat burning/oxygen use) and anaerobic (doesn't need oxygen to burn, so phosphate, glucose and lactate metabolism go in here). A paper in 2002 suggested that lactate was a big insulin resistance inducer - so no getting glucose into the cell with lactate around (AJP-Endo Articles in PresS. Published on April 30, 2002 as DOI 10.1152/ajpendo.00557.2001) But more recently, work shows that lactate suppresses glycolosis (conversion of glucose into pyruvate for ATP - in short conversion of glucose into energy) not insulin uptake. THis makes sense to me: one does lactate threshold training in endurance in order to be "glycogen sparing" - to be able to up the aerobic threshold (ability to rely on fat as fuel before cracking into the faster used up sugar supplies). Intriguingly, lactate is a by-product of anaerobic fuel burning that feeds back into the aerobic system for fuel. The better the aerobic system can utilize lactate the more effective and efficient and usually powerful it is. So, a paper in 2008 (EFFECT OF LACTATE ON INSULIN ACTION IN RATS) also looking at rodents showed that simultaneous exposure of insulin and lactate in the rats resulted in way more glucose uptake (which would suggest improved insulin sensitivity). That's a good thing. Related - a recent paper ([url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946576/?tool=pubmed]http://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmed[/url]) shows that working at lactate thresholod can be a good way to improve insulin senstivity. BUT also low instensity aerobic work reduced IGF (insulin like growth factor 1) and increased circulating IGFbp (igf binding proteins). SO - bottom line seems to be that, if muscles are working hard enough to say i'm running out of fuel; stick more glucose into me please, then glucose levels go up but genearlly speaking that elevation is going to come down after the demand has been satisfied unless the levels were a bit oversaturated to begin with. Lactate is a good thing that should not interfere with insulin but may reduce the need for glycolosis - thus that extra load may be floating around in the blood stream. And of course if you had any kind of recovery drink during or after the bout that will add too. Does that help? clear as mud? mc [/QUOTE]
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