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<blockquote data-quote="Winnie53" data-source="post: 1414873" data-attributes="member: 160246"><p>Kerrie, medications can cause side effects when you start them, but they can also deplete nutrients over time resulting in new side effects much later. After I read your posts, I wanted to see what nutrients are depleted by the medications you're taking. I found some information online - (see below) - but not much. This interview with Suzy Cohen, RPh explains the problem and is worth a read... <a href="http://www.lifeextension.com/magazine/2012/6/Drug-Muggers-Can-Slowly-Steal-Life-Out-Of-You/Page-01" target="_blank">http://www.lifeextension.com/magazine/2012/6/Drug-Muggers-Can-Slowly-Steal-Life-Out-Of-You/Page-01</a></p><p></p><p>I agree with Contralto that it's important to not take any nutritional supplements until you have your lab tests.</p><p></p><p>A big question I have is whether or not the Tramadol and Paracetamol is depleting any nutrients. I wish I had a good reference for this purpose, but I don't. Need to get a copy of Suzy Cohen's Drug Muggers book. Perhaps a pharmacist could provide that information.</p><p></p><p>You've got quite a few autoimmune conditions. I do too. For us, getting our vitamin D3 levels into range is really important to manage inflammation. For thyroid conditions, the minerals magnesium, selenium, and zinc - (possibly iron, but you'd need to be tested first because too much iron is problematic) - are important. Additionally, if gluten triggers your immune system to attack healthy tissue, such as your thyroid for example, it's my understanding that <em>any</em> exposure to gluten could trigger additional attacks. A book I like on how to live gluten-free is Dough Nation: A Nurse's Memoir of Celiac Disease from Missed Diagnosis to Food and Health Activism by Nadine Grzeskowiak, RN, BSN, CEN. To learn more, this is my favorite lecture by her - (its quite entertaining too)... </p><p></p><p>[MEDIA=youtube]KPqvhTuUEJU[/MEDIA]</p><p></p><p>Isabella Wentz, PharmD is a good resource for information about hypothyroid conditions and hashimotos. She has an excellent website. This article by her may be of interest to you... <a href="https://thyroidpharmacist.com/articles/top-9-takeaways-from-2232-people-with-hashimotos/" target="_blank">https://thyroidpharmacist.com/articles/top-9-takeaways-from-2232-people-with-hashimotos/</a></p><p></p><p>I would be concerned about the symptoms you're having too. I hope your doctor has a cancellation and can see you before the end of the month. Waiting is the worst. Do let us know what you learn as you get all these new symptoms sorted out. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p><p></p><p>Metformin (<em>Glucophage</em>)</p><p>Nutrients Depleted: Folic Acid, Dibencozide, Vitamin B12</p><p>Possible Mechanism: Malabsorption of dietary vitamin B12 and possibly folic acid.</p><p>Comments and References: The <em>Glucophage</em> package insert recommends obtaining hematological parameters annually and obtaining B12 levels at 2-3 year intervals in patients at increased risk for B12 deficiency. Symptomatic folic acid deficiency is unlikely. Give supplements only if clinical judgment warrants it.32,4490-1,7839,7841,8834,9520-3</p><p></p><p>Metformin (<em>Glucophage</em>)</p><p>Nutrient Depleted: Thiamine (B1)</p><p>Possible Mechanism: Theoretically, metformin might reduce thiamine activity.</p><p>Comments and References: This might result in more pyruvate entering the Kreb's cycle and being converted to lactic acid. This could contribute to metformin-induced lactic acidosis, but the process has not been substantiated in humans.9536,11466</p><p></p><p>Thyroid hormones:</p><p>Levothyroxine (<em>Levothroid</em>, <em>Levoxyl</em>, <em>Synthroid</em>, <em>Thyro-Tabs</em>, <em>Unithroid</em>)</p><p>Thyroid desiccated (<em>Armour Thyroid</em>)</p><p>Liothyronine sodium (<em>Cytomel</em>)</p><p>Nutrient Depleted: Calcium</p><p>Possible Mechanism: Increased bone turnover may lead to increased urinary calcium losses.</p><p>Comments and References: Calcium loss is unlikely to be clinically significant with doses of thyroid hormones used to treat hypothyroidism. Check thyroid function tests to ensure patients are not receiving excessive thyroid hormone doses, which may increase calcium losses.27-9,2684-5,2695,2697-8,2721</p><p></p><p><a href="http://naturaldatabase.therapeuticresearch.com/ce/ceCourse.aspx?pc=08-40&cec=0&pm=5&AspxAutoDetectCookieSupport=1" target="_blank">http://naturaldatabase.therapeuticresearch.com/ce/ceCourse.aspx?pc=08-40&cec=0&pm=5&AspxAutoDetectCookieSupport=1</a></p></blockquote><p></p>
[QUOTE="Winnie53, post: 1414873, member: 160246"] Kerrie, medications can cause side effects when you start them, but they can also deplete nutrients over time resulting in new side effects much later. After I read your posts, I wanted to see what nutrients are depleted by the medications you're taking. I found some information online - (see below) - but not much. This interview with Suzy Cohen, RPh explains the problem and is worth a read... [URL]http://www.lifeextension.com/magazine/2012/6/Drug-Muggers-Can-Slowly-Steal-Life-Out-Of-You/Page-01[/URL] I agree with Contralto that it's important to not take any nutritional supplements until you have your lab tests. A big question I have is whether or not the Tramadol and Paracetamol is depleting any nutrients. I wish I had a good reference for this purpose, but I don't. Need to get a copy of Suzy Cohen's Drug Muggers book. Perhaps a pharmacist could provide that information. You've got quite a few autoimmune conditions. I do too. For us, getting our vitamin D3 levels into range is really important to manage inflammation. For thyroid conditions, the minerals magnesium, selenium, and zinc - (possibly iron, but you'd need to be tested first because too much iron is problematic) - are important. Additionally, if gluten triggers your immune system to attack healthy tissue, such as your thyroid for example, it's my understanding that [I]any[/I] exposure to gluten could trigger additional attacks. A book I like on how to live gluten-free is Dough Nation: A Nurse's Memoir of Celiac Disease from Missed Diagnosis to Food and Health Activism by Nadine Grzeskowiak, RN, BSN, CEN. To learn more, this is my favorite lecture by her - (its quite entertaining too)... [MEDIA=youtube]KPqvhTuUEJU[/MEDIA] Isabella Wentz, PharmD is a good resource for information about hypothyroid conditions and hashimotos. She has an excellent website. This article by her may be of interest to you... [URL]https://thyroidpharmacist.com/articles/top-9-takeaways-from-2232-people-with-hashimotos/[/URL] I would be concerned about the symptoms you're having too. I hope your doctor has a cancellation and can see you before the end of the month. Waiting is the worst. Do let us know what you learn as you get all these new symptoms sorted out. :) Metformin ([I]Glucophage[/I]) Nutrients Depleted: Folic Acid, Dibencozide, Vitamin B12 Possible Mechanism: Malabsorption of dietary vitamin B12 and possibly folic acid. Comments and References: The [I]Glucophage[/I] package insert recommends obtaining hematological parameters annually and obtaining B12 levels at 2-3 year intervals in patients at increased risk for B12 deficiency. Symptomatic folic acid deficiency is unlikely. Give supplements only if clinical judgment warrants it.32,4490-1,7839,7841,8834,9520-3 Metformin ([I]Glucophage[/I]) Nutrient Depleted: Thiamine (B1) Possible Mechanism: Theoretically, metformin might reduce thiamine activity. Comments and References: This might result in more pyruvate entering the Kreb's cycle and being converted to lactic acid. This could contribute to metformin-induced lactic acidosis, but the process has not been substantiated in humans.9536,11466 Thyroid hormones: Levothyroxine ([I]Levothroid[/I], [I]Levoxyl[/I], [I]Synthroid[/I], [I]Thyro-Tabs[/I], [I]Unithroid[/I]) Thyroid desiccated ([I]Armour Thyroid[/I]) Liothyronine sodium ([I]Cytomel[/I]) Nutrient Depleted: Calcium Possible Mechanism: Increased bone turnover may lead to increased urinary calcium losses. Comments and References: Calcium loss is unlikely to be clinically significant with doses of thyroid hormones used to treat hypothyroidism. Check thyroid function tests to ensure patients are not receiving excessive thyroid hormone doses, which may increase calcium losses.27-9,2684-5,2695,2697-8,2721 [URL]http://naturaldatabase.therapeuticresearch.com/ce/ceCourse.aspx?pc=08-40&cec=0&pm=5&AspxAutoDetectCookieSupport=1[/URL] [/QUOTE]
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