We were told that the insulin would go off if left in the plastic cartridges for more than a few days. I think it separates or something so will become less effective.Cheryl said:I tend to get a slight lump after 2 days & the sites were taking weeks before the marks faded. I was advised by my DSN to change the cannula every 2 days as a matter of course & this has made a definite difference. There's no reason to be wasting insulin though if you change just the cannula & not the whole tubing/cartridge set. (of course I don't know what pump you have & which sets you use to know your exact set up) I treat cannula changes & cartridge/tubing changes completely separately changing the cannula every 2 days & cartridge/tubing every 7 to 8 days when it's almost empty.
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