) At what point does Hypo/low BGL become a serious issue/unable to self-treat?
Hypos, even the mild ones, are
always serious issues, requiring immediate treatment, because they might seem mild but can rapidly become way more messy if not treated. The treatment to stave that off might be as little as 5 to 10g, but don't ever think, ooh, bit low, leave it till later, I'll be fine.
There's a surprisingly thin line between feeling a bit low, and being on the pavement, but if you pay attention to the initial onset symptoms and get some sugar in your face quick, you can turn it round pretty quickly. Don't be terrified of hypos: they will happen, it's inevitable and sometimes they'll be messy but there's nothing some heavy duty sugar can't sort out.
Don't view it in terms of numbers or points - you'll know when it becomes untreatable, because you'll be unable to treat it.
Actually, it's not as easy as that. Sometimes, you'll be so far out of it, you'll not know you're needing treatment. On those occasions, unless you're away camping in the wilds of Alaska, rest assured that people will step in and help.
If you're on your own, that can get messy, but the usual outcome is that the insulin on board will wear out after 4 to 5 hours, adrenalin kick/liver dump will raise it, and you'll wake up soaked in sweat thinking what the **** just happened there.