Based on personal experience, Gliclazide can cause hypos, but it all depends on your individual context. I took maximum dose of Gliclazide just before bed way after my last meal and then first thing in the morning without having any food until lunch. As my blood glucose was way out of control, none of this mattered too much. Within weeks of starting low carb, I first had to reduce and then completely stop Gliclazide as it was pushing me into the hypo territory. While I'm a proponent of choice of how you treat your long-term conditions, I'd recommend discussing your treatment changes with your healthcare team. Unless you fully understand how different drugs work, interact with other treatments (including your diet), and you are closely monitoring how your body responds to any change in your approach, Gliclazide is one of those medications you need to be careful with.