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C-Peptide - enhances glucose disposal and metabolic control

Dillinger

Well-Known Member
Messages
1,209
Location
London
Type of diabetes
Type 1
Treatment type
Insulin
Dislikes
Celery.
Just found this whilst reading up on retinopathy in relation to another topic.

So, could C-Peptide's absence in Type 1 diabetics help explain some of the complications suffered? Anyone else heard of this?

http://www.ncbi.nlm.nih.gov/pubmed/19243312
 
Re: C-Peptide - enhances glucose disposal and metabolic cont

http://care.diabetesjournals.org/conten ... 1.abstract

So, C-peptide treatment for 6 months improves sensory nerve function in early-stage type 1 diabetic neuropathy. That was the result of a 2006 study; and the consequences? Er, absolutely nothing... :roll:

[edit] - Ah, OK maybe not absolutely nothing; here's a piece about C-peptide therapy from 2010

http://asweetlife.org/a-sweet-life-staf ... apy/11104/

Still, it's not something my GP has mentioned...

Dillinger
 
Re: C-Peptide - enhances glucose disposal and metabolic cont

quite short but this DUK appeal video is about research into it.
[youtube]YXhzyf02peg[/youtube]
and some companies are trialling synthetic c peptide for neuropathy
http://www.creativepeptides.se/company.html
 
Re: C-Peptide - enhances glucose disposal and metabolic cont

The hubris of the medical profession in relation to the magnificence of the human body never ceases to amaze me; here's something (c-peptide), we don't know what it does, so we're just going to assume it must be rubbish because we know all about how this works and it doesn't fit into our view...

Another good one is the how the body very carefully controls the blood sugar range (and this been in place since when? Early man 100 - 250,000 years ago, early mammals 65 million years ago? Earlier than that?) but the medical profession says 'well, we're going to ignore all that and say it's fine for diabetics to have between 50% to 100% higher levels that those of non diabetics, because, er, because we say so'.

Dillinger
 
Re: C-Peptide - enhances glucose disposal and metabolic cont

Dillinger
the reason [well the one I've heard] for setting high targets for bg in diabetics is even less creditable than " we say so".
I'm told the source of this info was a past president of the American diabetes Association.
On being asked for the reason for setting these targets, he's supposed to have said that everyone knows diabetes kills. So if the patient dies of diabetic complications, that's just the etiology of the condition. However if the patient dies as a result of too much insulin, that's the doctor's fault for prescribing it. so you can sue the doctor.
In other words, the NHS has set us up with targets which were initially decided on to protect the American medical profession from lawsuits.
Shocking!
I can't verify any of this. I just read it somewhere.
Hana
 
Re: C-Peptide - enhances glucose disposal and metabolic cont

The targets to a certain extent are set by plotting all the complications of diabetes against HbA1c levels... They've been doing this since the HbA1c's were done, our HbA1c's are constantly collected and reviewed every 2 years! So far, since HbA1c's been available there's a constant U shape, to the left is complications associated with low levels/hypo's to the right is the other long term complications... Top of the U is the high figures, at the bottom of the U is the 6.5-7%... Hence why we get told that this is considered good control, as go one way or the other you can start hitting problems at a greater rate.

Here's another piece of research just released concerning C-petide and prediction of T1 diabetes..

http://care.diabetesjournals.org/conten ... 0011.short
 
Re: C-Peptide - enhances glucose disposal and metabolic cont

Hi.

Heres a biochemical explanation for the importance of C-peptide in type 1 diabetics:

http://www.youtube.com/watch?v=yXTocbIM-6w&t=31m55s

The peak info starts at 25min30s (the whole lecture is great info too)

[flash=420,315]http://www.youtube.com/v/yXTocbIM-6w?version=3&hl=fi_FI[/flash]
 
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