Well....I spoke to the hospital about it and they were saying it shouldn't happen, and when I took out the bit from the canula to load up my data to diasend I noticed there was some blood in the tube/canula bit that goes into you. This is not the 1st time - I had one set fail probably because of blood, and I have noticed blood mixed in with the insulin when I have pulled old canulas out (so at least 3 in the last couple of weeks), so the hospital were saying to give the angled ones a try when I pop in to see them in a week or so as the blood thing shouldn't be happening (I am not the biggest of people and had to have a paediatric drip when I had my kids as they punctured me several times before concluding that a normal one wasn't going to work!) Also on a few of the canulas I have felt insulin go in when I bolus, and on one it hurt when it went in so I pulled that one out fairly sharpish! There is a level of stress with a set change, but not stressful enough for a spike I don't think...stress can also make me drop too - I was more stressed changing them on my holiday than I have been at home where I feel fairly relaxed about it all and the spike still happens! I am hoping an angled canula is the answer...for now I am going to try and find really fatty areas to put it!