Hi Lilyfleur
I use Enlite sensors and often find approximately the first 6 hours give me a bigger difference between interstitial glucose levels and blood glucose. It then usually settles down and is pretty accurate after that increasingly so the longer the sensor has been working.
If the difference in glucose meter and CGM readings are vastly different you will get a calibration error message after which the sensor warms up again for a short period. I haven't had many of those but usually it resets at a more accurate level. If the accuracy doesn't improve and you can't contact your DSN I would give Medtronic a ring as they have helped me out with sensor problems before. I hope you get better accuracy from it soon.