@Bluetit1802 Indeed there are a few 'nom de plumes' of vascular disease.
You have described intermittent claudication which more often arises from the larger arteries higher up the leg, the smaller more distal arteries, tend to cause the foot problems.
Peripheral disease also affects the carotid arteries, both internal and external, this is often overlooked. A completed stroke can be the outcome of a carotid occlusion of >85%. This is sometimes termed extra-cranial vascular occlusion, to differentiate from intra-cerebral stroke.
Whilst high blood sugars - as you so rightly point out - do damage to the legs by their inflammatory effect on the endothelium, the greatest number of amputations are carried out due to occlusive disease by fats. This is known because whenever a surgeon does a vascular procedure the tissue goes to the laboratories to be inspected and reported.
You have described intermittent claudication which more often arises from the larger arteries higher up the leg, the smaller more distal arteries, tend to cause the foot problems.
Peripheral disease also affects the carotid arteries, both internal and external, this is often overlooked. A completed stroke can be the outcome of a carotid occlusion of >85%. This is sometimes termed extra-cranial vascular occlusion, to differentiate from intra-cerebral stroke.
Whilst high blood sugars - as you so rightly point out - do damage to the legs by their inflammatory effect on the endothelium, the greatest number of amputations are carried out due to occlusive disease by fats. This is known because whenever a surgeon does a vascular procedure the tissue goes to the laboratories to be inspected and reported.