I'm in the mainland USA, and order Creon in 3 month supply. Because of quantity, it is always a "special" order, but usually takes just a couple of days to complete. (I also keep a couple months extra supply in case of insurance problems.) I wonder if your wholesale supplier problem has anything to do with the situation in Puerto Rico. Lots of drug manufacturers have factories there, including Abbvie who produces Creon. They also have several manufacturing sites in Europe, so if may just be more of a local issue. As for Creon being an important part of our regime - I agree. I don't digest food without it, and would have little quality of life without it. I hope your supply issue is resolved soon.