Initially my ED was as a result of my diabetes. 100mg sildenafil worked very well for me, until I was diagnosed with multiple myeloma. The Sildenafil continued to work at first, despite the chemotherapy. However, as time has gone on, the changes in chemotherapy (on my third different regime) slowly killed my desire and ability to perform. At my last meeting with my consultant I asked her when would I get love life back. She replied, sadly Ian, you may not. 65 and on the scrap heap.