How insulin works

drahawkins_1973 · Nov 18, 2014

HI all

I posted this reply to a quesiton about chemical structres etc of insulin but thought it mgiht be of interst to others. I was orginally researching how tresiba works but there is interesting info on other insulins too.

Andrea
http://asweetlife.org/feature/insulin-like-a-string-of-pearls-how-degludec-works/

robert72 · Nov 18, 2014

drahawkins_1973 said:
HI all

I posted this reply to a quesiton about chemical structres etc of insulin but thought it mgiht be of interst to others. I was orginally researching how tresiba works but there is interesting info on other insulins too.

Andrea
http://asweetlife.org/feature/insulin-like-a-string-of-pearls-how-degludec-works/

Awesome

drahawkins_1973 · Nov 18, 2014

robert72 said:
Awesome

It's really clever isn't it. I couldnt get my head around why Tresiba lasted so long but makes more sense now!

tim2000s · Nov 18, 2014

Great article that one. Wonder when Degludec will be available?

robert72 · Nov 18, 2014

tim2000s said:
Great article that one. Wonder when Degludec will be available?

I've been using it since June - it's been available since I think early last year

tim2000s · Nov 18, 2014

Interesting. Need to get on to someone about that. Thanks Robert.

PS - Your signature says Tresiba!

robert72 · Nov 18, 2014

tim2000s said:
Interesting. Need to get on to someone about that. Thanks Robert.

PS - Your signature says Tresiba!

Same stuff - it's more expensive than Levemir/Lantus so you'll probably need to make a case for it

But I can thoroughly recommend it

tim2000s · Nov 18, 2014

Making a case is relatively straightforward, and of course, with the libre we can manage our blood glucose to help us make the case....

phoenix · Nov 18, 2014

Thank you, that's well written,
I had a look for some illustrations that might help clarify some things .
insulin monomer, dimer, hexamer
http://en.wikipedia.org/wiki/User:Honfaichan#mediaviewer/File:Insulin_monomer_dimer_hexamer.tif
diagram of how lantus is absorbed.
http://www.diapedia.org/management/insulin-glargine
an animation showing what happens after injection with Tresiba (slides 16-18)
http://slideplayer.us/slide/222440/

smidge · Nov 18, 2014

Thanks for this information. It is great timing for me. I raised the issue of unpredictable BGs on Levemir with my DSN this morning while she was fitting a CGM to see what on earth is going on with my BGs. She was very luke warm about Tresiba - basically telling me they're waiting for trials on some of their patients to finish; that it's most suitable for people with erratic lifestyles blah blah blah. I didn't push it, but when I see my consultant next month after I know the outcome of my sensor results, I intend to make a very strong case for Tresiba and if they won't switch me to it, I'll ask to switch to the consultant who is trialling it on his patients. I might not have an erratic lifestyle but I do have erratic BGs. My Libre shows my patterns like a stormy Atlantic, so I'm hoping that will be enough to convince them. Is it much more expensive than Levemir? What arguments have others used to get on it?

Smidge

drahawkins_1973 · Nov 18, 2014

smidge said:
Thanks for this information. It is great timing for me. I raised the issue of unpredictable BGs on Levemir with my DSN this morning while she was fitting a CGM to see what on earth is going on with my BGs. She was very luke warm about Tresiba - basically telling me they're waiting for trials on some of their patients to finish; that it's most suitable for people with erratic lifestyles blah blah blah. I didn't push it, but when I see my consultant next month after I know the outcome of my sensor results, I intend to make a very strong case for Tresiba and if they won't switch me to it, I'll ask to switch to the consultant who is trialling it on his patients. I might not have an erratic lifestyle but I do have erratic BGs. My Libre shows my patterns like a stormy Atlantic, so I'm hoping that will be enough to convince them. Is it much more expensive than Levemir? What arguments have others used to get on it?

Smidge

I'm having issues with my levemir too. Noblehead and Robert suggested tresiba so that's why I was reading up about it. I have an appointment Friday with GP and I'm going to ask for it too. I suspect he'll push for me to try lantus as it's cheaper. It's about £72 for 5 pens of tresiba vs about £42 ish for the others. ( I think- Rob posted the prices in a previously).
Will let you know how I get on. Good luck for you getting it too!
Andrea

Sent from the Diabetes Forum App

Brunneria · Nov 18, 2014

Brilliant article.

Thanks for highlighting it!

tim2000s · Nov 18, 2014

Anyone know what the phial price of tresiba and lantus are? Mine is a bit old school due to dosage.

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