Hmm well I am still on holidays, so if I take Lantus at 11-12 midnight, it is not a problem at all because I stay up pretty late till around 3 or 4 am. Anyway, when i am back on campus, i tend to eat dinner by 7 or 7:30pm so Lantus should be around 10 or so, bedtime by midnight definitely because I am not used to sleeping earlier than midnight.Why don't you move your Lantus injection to an earlier time?
I know, from a previous discussion, you are concerned about taking it with your bolus for your evening meal but you can move it to any time of the day: I remember you saying you don't notice the peak after 3 hours so you should not be concerned about it.
I know I used to take it at bed time because this was when I did habitual things like cleaning my teeth. However, as I am not habitual with my bed time, this meant I was taking it at a different time every day.
As a result, I just chose a time and stuck to it as much as possible rather than sticking to an event.
Wait, Lantus dropped sugar by 50% its initial value? WHAT IN HEAVENS NAME?This says the crystallisation happens rapidly
"Following subcutaneous injection, insulin glargine is rapidly metabolized into its two main active metabolites: M1 (GlyA21) and M2 (GlyA21, des-ThrB30) [97], with little or no glargine molecule being detected in the systemic circulation. The M1 metabolite accounts for approximately 90 % of the available daily plasma insulin [97], and its release from the poorly soluble parent compound is the primary mechanism, resulting in the pharmacokinetic characteristics and consequent pharmacodynamic effect with the long-acting time–action profile observed with insulin glargine treatment [98–100]. Steady state is attained within a few days [101]. Importantly, adverse events, injection-site reactions, and antibody formation with insulin glargine were found to be comparable with NPH [75]."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045187/
Logically it would have to be a very rapid process, because otherwise other things would start to happen. I would assume it's pretty fast.
Wait, Lantus dropped sugar by 50% its initial value? WHAT IN HEAVENS NAME?
Wait no this might explain till some level the drops I get with Lantus and then I finally get to know that this is how it is supposed to be. At least I have an answer now! I can use that piece of information for my good.Oh no, I haven't given you more to worry about have I? Levemir works in a different way, it may give you a better night's sleep, even if it's not perfect.
I don't think worrying about your long acting insulin not behaving like a long acting insulin is a good thing.
Wait no this might explain till some level the drops I get with Lantus and then I finally get to know that this is how it is supposed to be. At least I have an answer now! I can use that piece of information for my good.
Oh wow I keep it outside the fridge as well. InterestingI've found recently with the heat, that if Lantus is kept in 37ish degree heat for around a week (I kept it in my room, whilst on holiday in the south of France; didn't put any spares in the fridge) it must lose its ability to crystallize.
When I injected it, it had the effect of short acting insulin; causing lots of hypos shortly after (I inject 16u Lantus, whereas I follow a low carb diet and don't usually inject more than 3 u of NovoRapid). I inject Lantus in the morning and overnight my BGs with going into the 20s (extremely unusual for me). As soon as I got home, I had some stuff from the fridge and I was back to good control again.
Lesson learned, keep out of heat and in the fridge.
Oh wow I keep it outside the fridge as well. Interesting
You are making me feel badFYI Levemir and Tresiba don't have any of these problems, they are all unique to Lantus.
Haha not my intention, just sayin there are other options. Lantus was the first basal analogue and I think the method it works is inferior to newer options. Absorption is variable depending on the injection site and it can drop someone dangerously low after injection. There was that cancer scare. I have no idea how real that is and understand all analogs may have a cancer risk, but Lantus has been specifically cited in a study. I think the company is pretty disgusting patenting a new basal, Toujeo, which is just 3x concentrated Lantus and trying to block another company from selling a generic version of Lantus. All pharma companies have disgusting practices though I admit.You are making me feel bad
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