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Type 2 LCHF Issues

@Kristin251 can you remember where my summary of mTor that I wrote for you is located?


Diagnosed 13/4/16: T2, no meds, HbA1c 53, FBG 12.6, Trigs 3.6, HDL .75, LDL 4.0, BP 169/95, 13st 8lbs, waist 34" (2012 - 17st 7lbs, w 42").

6/6/16: FBG AV 4.6, Trigs 1.5, HDL 2.0, LDL 3.0, BP 112/68, BPM 66, 11st 11lbs, waist 30".

Regime: 20g LCHF, run 1 mile daily, weekly fasting.
 
I'm on.y guessing here Kevin but maybe the thread I started called ' how much protein do you eat' or something like that. I was thinking about it too but haven't had time to search for it
 
I too find fish spikes me more than I expected. Worst is Mackerel, and salmon, bur i seem ok on Brisling, Sild, and pilchard, even Kippers are fine. Tuna is midrange for me, We love Bassa fish here.

I was also shocked at how much a single fish finger spiked me, but i am ok with jumbo battered fish from the chipshop.
 
@evelygtc,

Here's a simpler summary of a more comprehensive analysis of mTor I provided for Kirstin251:

How much protein do you eat
I've read and watched numerous videos about the discovery of the mTOR pathway and the two variants lower in the path mTORC1 and mTORC2.

For those following this thread here is a basic definition mTORC:

The mechanistic target of rapamycin, also known as mammalian target of rapamycin (mTOR) is a protein that in humans is encoded by the MTOR gene. MTOR is a serine/threonine protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, transcription. MTOR belongs to the phosphatidylinositol 3-kinase-related kinase protein family, and fibrosis.

Dr Sarah Hallberg talks clearly and lucidly explains the pathway for cell action and survival and the impact of insulin etc. a Google search will enable followers of the thread to get a better understanding of its importance.

http://www.diabetes.co.uk/forum/index.php?posts/1146718/

This might help you understand a bit more of the context


Sent from my iPad using DCUK Forum mobile app
 
Yup salmon. Albacore raises me more than skipjack. Perhaps the harder foods are to digest the higher we go. Or maybe something with the omega 3 fats. Or maybe the size of the fish, the bigger the fish the bigger the spike. It's also weird lamb doesn't spike me at all. I have never heard of Bassa. Is it white ? I don't seem to have problems with white fish.
 
Basa is a white fish like Cod, but smaller. Better if I had spelt it right.

"The basa fish (Pangasius bocourti) is a species of catfish in the family Pangasiidae. Basa are native to the Mekong and Chao Phraya basins in Indochina. These fish are important food fish with an international market." - Wikipedia

We coat ours in crushed Cornflakes, then bake in the oven. Delicious with lemon juice sprinkled on it. And it has virtually no rise in my bgl. Got the recipe from the DCUK Christmas recipes 2015, Brilliant !!!!!
 

@KevinPotts I found the thread where you describe mTor.

http://www.diabetes.co.uk/forum/threads/please-help-very-awkward-question.98301/page-3
 
Winnie53 said:
@KevinPotts I found the thread where you describe mTor.

http://www.diabetes.co.uk/forum/threads/please-help-very-awkward-question.98301/page-3
Click to expand...

Well done..better searching skills than me...or was it your amazing memory?


Diagnosed 13/4/16: T2, no meds, HbA1c 53, FBG 12.6, Trigs 3.6, HDL .75, LDL 4.0, BP 169/95, 13st 8lbs, waist 34" (2012 - 17st 7lbs, w 42").

6/6/16: FBG AV 4.6, Trigs 1.5, HDL 2.0, LDL 3.0, BP 112/68, BPM 66, 11st 11lbs, waist 30".

Regime: 20g LCHF, run 1 mile daily, weekly fasting.
 
Here is just that extract:

mTor is a pathway that as I understand it is a bit like a central controller of cell growth, metabolism, proliferation right down to survival in every thing from yeast to all mammals. As such it plays a key role in development and ageing.

Sabatini discovered that the pathway is activated during certain cellular processes such as cancer causing tumour formation and insulin resistance to name a couple. It is deactivated in full blown diseases such as cancer and T2. Clinically, developing inhibitors of mTor such as rapamycin, has received a lot of attention with an emphasis on helping deal with solid tumours, coronary disease, transplants etc.

It has also been implicated in disorders such as cancer, cardiovascular disease, obesity, and diabetes.

The current challenge from what I've read seems to be to understand the role of mTOR signaling to coordinate and integrate overall body growth in multicellular organisms.

David Sabatini's work started with identifying that mTor was the target of the rapamycin molecule. It is this molecule that has been found effective as an immunosuppressant, anti- cancer, prolonging life in model animals (mice etc). It looks like a strong possibility that in view of the life prolonging research, there maybe an FDA approved molecule including the rapamycin property.

So as Sabatini explains this complicated pathway:

1. Nutrients, oxygen, energy and growth factors interact with mTor which is directly bound by rapamycin

2. The most interesting part for Sabatini, is that the pathway has the capacity to sense EVERYTHING. Any kind of growth factor, nutrient, stress, DNA damage everything. Somehow this system recognises it and that tells us that the cell cares a lot about regulating this system.

3. In addition, mTor is involved in all the processes in the cell that either use or make energy. So in a nutshell, this is the key pathway in regulating cell physiology.

So the driver of this process is typically food (either manipulated by caloric restriction) or obesity or different types of diet to the balance between an anabolism (the work of the liver on life supporting balance from the broken down molecules) v catabolism (process of breaking down molecules and transporting to the liver).

Thinking of our conditions of course, insulin falls within the "growth factor" category.

His more recent work has included the fact that what he calls "Caloric Restriction" prolongs life in all life, from stem cells to humans as part of a lifestyle of caloric reduction.

He and is team found that as one example the stem cells in the lining of the gut respond well to reducing calories. The amount and activity of these cells decreases. His particular interest has been that this type of cell, is usually the origin of cancer causing cells and when mutations occur the cell is transformed and acquires cancer like properties. This is called tumour initiation leading to tumour growth. Thus prolonged calorie restriction reduces the incidence of tumours, prolonging life and the two major pathways play their critical part on every occasion.

Yes there are 2, mTorc1 and mTorc2.

Both pathways are surrounded by a variety of different mutations found commonly in cancer. Insulin operates with mTorc 2.

So, a pathway such as this has to sense two types of classes of molecules to make the decision to grow or Not grow via nutrient intake and hormones such as insulin and make a decision as to whether both are present (nutrient and hormone) and so drive growth. All these factors signal to the cell via a number of steps along the pathway and thus the impact of this pathway, triggered by nutrients and hormones leads to the balance of our bodily systems and ultimately survival.

That's about the most succinct way I as an amateur is able to describe its place and importance.

Certainly the presentations of Dr Sarah Halberg that I mentioned previously focus in more on its impact for us as diabetics.

I hope I've been clear enough....if not my apologies.







Sent from my iPad using DCUK Forum mobile app


Diagnosed 13/4/16: T2, no meds, HbA1c 53, FBG 12.6, Trigs 3.6, HDL .75, LDL 4.0, BP 169/95, 13st 8lbs, waist 34" (2012 - 17st 7lbs, w 42").

6/6/16: FBG AV 4.6, Trigs 1.5, HDL 2.0, LDL 3.0, BP 112/68, BPM 66, 11st 11lbs, waist 30".

Regime: 20g LCHF, run 1 mile daily, weekly fasting.
 
@KevinPotts I really liked your description and wanted to find it again. Fortunately, I don't post often so I simply looked at all the threads I've posted on recently.

I really like the way you describe it. And it helps to read it when my mind is clear, free from day-to-day distractions. It's funny, my friends make fun of me when we get together each Friday because I'm so careful about the quality and type of food I eat now. Reading your clearly written overview validates everything I'm doing right now. It keeps me inspired to continue eating as healthily as I can.

I have questions for you. Tonight I'm realizing that mTor is contained within the cell. What types of cells? By that I mean are they cells primarily associated with our various organs?
 
The mTor pathway INTEGRATES both "in cell" and "out of cell" signals and so acts as a regulator, like a central controller.

But it is ACTIVATED by cellular activity.

This link will take you to a graphic of the entire impact of this important pathway. I only understand it st its most basic level

http://d1dvw62tmnyoft.cloudfront.ne.../F1.large.jpg?width=800&height=600&carousel=1


Diagnosed 13/4/16: T2, no meds, HbA1c 53, FBG 12.6, Trigs 3.6, HDL .75, LDL 4.0, BP 169/95, 13st 8lbs, waist 34" (2012 - 17st 7lbs, w 42").

6/6/16: FBG AV 4.6, Trigs 1.5, HDL 2.0, LDL 3.0, BP 112/68, BPM 66, 11st 11lbs, waist 30".

Regime: 20g LCHF, run 1 mile daily, weekly fasting.
 
Oh wow Kevin, that's a beautifully detailed graphic. Thank you.

After a year of watching my health improve, my husband's now digging into the research so will share this with him too. It's a long story, but one of my husband's interests is corresponding online with people who are living with ALS, a condition neither of us has, also with sleep apnea, a condition he does have.

I'm going to try to make what sense I can of the graphic later this weekend.

Just took my husband to the graphic. He's a happy boy. Thanks again Kevin.
 
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