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Mounjaro

I just started on Mounjaro for the second time a week ago today. The first time, I ended up in the hospital for several days with atrial fibrillation and severe diarrhoea and vomiting after starting the 5mg dose. Now I'm not 100% sure whether the Mounjaro caused these problems. The doctors say the atrial fibrillation was likely caused by dehydration from the diarrhoea and vomiting. I had no bad symptoms when on the 2.5mg dose. Now, on the second attempt, my fasting blood sugar has reduced from around 10 mmol/l to just over 6 mmol/l after 1 week. I've lost 2.5 pounds, and my food cravings have all but disappeared. This is much the same as during the first time on Mounjaro. The diabetes team has agreed to let me stay on the 2.5mg dose if I am still seeing positive effects. I will only have another go with the 5mg dose if I'm not getting continuing benefits on 2.5mg. I acknowledge there are risks, but the improvements I saw during the first go make me think the risk is worth at least one more attempt.
 
is your BMI highter than 27. mine is 27bmi but my GP refuse unless its 32BMI. i suffer from extreme hunger pangs. T2 with high swings especially Dawn Phenomenon is Extremely hight and long.wakeup with 5-5.5 and within hour its starts spikes to 15 and then its take 8 hours to lower to 7 again..then i eat and again start rising to 15 , eat gliclizide tablet and next few hours it lower again..but high and lows destry my health.
 
Yep I’ve been on it since mid March. I’d applied to my local pharmacy to pay for it myself then I had a phone call from my GP to say I fulfilled the NICE guidelines so could have it on the nhs!
@mycanal my bmi was 35.8 at that time but has now gone down to 33.5.
BG is now in the 5s and I’ve lost just over a stone. Blood pressure hasn’t changed much though. I would have liked to have lost a bit more weight but I haven’t exercised much and I am really bad at drinking lots although working on that.
But the biggest side effect is the ‘food noise’ has completely gone, for instance, I walked down an aisle of Easter eggs and didn’t even think of buy any! Result! lol!
 
I started 3 months ago on the 2.5mg injections and the insulin I needed reduced immediately along with the weight loss. I stayed on 2.5 for 3 months to help ensure I could manage without any complications. After 12 week I have now switched up to 5mg injections without any major issues. Obviously I do have some side effects like acid reflux and constapation, but these are easily manged. My insuling requirements have dropped from a 3-1 ratio to a 1-1 and steady weight loss.

The most difficult issue has been controlling low blood sugar events. Because eating to raise your BS is so slow it doesn't work, I have to use high sugar content drinks or Dextrose in water.

Extremly happy with the results at nearly 2 stone lost and insulin resistance has gone.

History: Type 1 for 54 years with a1c of 46 and time in range over 90% with multiple injections, bad bits high BMI and increasing insulin resistance.
 
Been on it since it became available on the NHS now on 15mg highest leval and the difference is unbelievable lost just over a stone slowly working on losing more I use nutracheck for a low carb diet excellent app to use measures all meals I use the scanner patch on my arm sending readings to my phone which are now nearly perfect 4.5 to 6 and my last hb1ac came back at 5.1 I don't excersise much due to legs being full of plates screws and pins but try and do as much as I can walking half a mile most days some days a mile o yea I have multiple injects a day novarapid x3 toujeo x1 and making adjustments all the time
 
I was changed from Trulicity onto Mounjaro a little while ago. I started on 2.5, which wasn't really effective, so I had 2 months on 5.0, which was starting to curb my appetite, but it was agreed I would try the 7.5 dose. I took my first 7.5 dose of Mounjaro at 9pm last Monday evening the 16th June, and from Tuesday onwards my appetite was almost nil. All the foods I normally enjoy I didn't desire, and the foods I was eating didn't taste "right", as if to stop me from overeating. I found I was quite quickly full, but if I ignored the sign to stop eating, I felt very bloated and uncomfortable afterwards.

In all the time I have been on the Mounjaro, I have either dropped a pound or two in weight here and there, or I have remained the same, which wasn't very encouraging (at least I wasn't gaining weight). My first dose of 7.5 was 7 days ago, and when my wife weighed me on Saturday morning, as usual, I had lost 5 pounds. 5lbs in less than a week! Yes I was happy with the result, but shocked by how much I'd lost. Looking back on the week tho, all I fancied for breakfast was a slice or two of toast, and I was having a bread roll with a bowl of soup for my evening meal. The most important breakthrough was, I wasn't snacking of an evening.

I am on medication for Arthritis, Diabetes (which is well controlled now), Asthma and Myeloma, for which I'm currently on maintenance chemotherapy. I'm waiting for knee surgery and until my HbA1c was under 69 I couldn't have that surgery. My diabetes team have helped me reduce my HbA1c from 71 to 62 and have written to the surgeon requesting that I be added to their list.

I have a friend who is also on Mounjaro, and he has lost just shy of 3st, but he is currently on the 10.0 dose. He has been taken off his Metformin, and they are now going to introduce him to a "maintenance" dose of Mounjaro to maintain his current weight. I can see that it has worked for him and I'm now hoping it will help me.
 
Grandadfatboy sounds like it's working now for you I was on trulicity before being changed and took some getting used to the small portions of food at meal times and always feeling full but soon got used to it and stated to find meals I enjoyed for example a dinner time meal was 3 toast beans and 2 poached eggs now that meal is 1 toast and 1 poached egg another enjoyable meal is a few new potatoes and a piece of fresh fish basically it's a case of think what you used to enjoy and reducing the portion size
Good luck on your goals just stick with it and you will achieve them
 
I have been on it since March at the suggestion of my practice nurse. Currently on my second 5.0 pen. It hasn't cured my sweet tooth and weight loss has been very modest but like mycanal it has really solved the dawn spikes which nothing else seemed to shift. My cgm shows 95% time in range at the moment and I have stopped my metformin. Unexpectedly my IBS symptoms which had really effected my day to day life have improved (pre dated metformin). I had read that there is an anti inflammatory effect from mounjaro.
 
Flowergarden I started on 10 mg followed by 12.5 ending on 15mg while on the lower doses weight dropped very slowly but my insulin dropped quite a lot once I got onto 15mg within 6 weeks I had lost 14lb and halved my insulin intake taking my hba1c down to 49 mmol improving my day to day lifestyle massively so stick with it and hopefully your goals will be reached good luck Flowergarden
 
Nice if it works for you. I had a trial a couple of months ago. Took my dose on Sunday, didn't notice anything. Monday I felt ill, feeling like my stomach wanted to empty - it didn't. I didn't eat anything all day. Tuesday it was so bad I went to the doctor who promptly sent me to hospital. They did a load of tests and concluded the Mounjaro wasn't suitable for me and I should not take any more. I was out the same day, but it took days to recover.
Prior to that my blood sugar was consistently around 7.5 - during and after it was around 12. Only this month have I got it back down after increasing my gliclazide to the maximum dose. A disaster all round and I wish I'd never seen it.
 
It's my intention to remain on 2.5 mg unless I find the positive effects I'm currently experiencing starting to wear off. I didn't realise there was a 3.5 mg dose. It doesn't mention 3.5 mg in my mounjaro guide pamphlet.

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I was prescribed Mounjaro as my bloods were running riot. I've been on it since March, coupled it with a low carb diet and had minor side effects. Within 3 days of taking Mounjaro my bloods came right down. After 4 weeks the dose was increased to 5 mg which I'm still on. During that time I've lost nearly 11 kg (4 kg to go until I reach my BMI target of "normal"), and feel great. Also a great success factor for me is that I've gone from 110 units Toujeo daily to just 20 now. Carb ratios in the morning with Novorapid have stayed the same (1:2) but at dinner time I've been experimenting with no insulin but keeping to a maximum of 35-40 g carbs and this seems to be working. This drug has been a real game changer for me.
 
Hi
Hi JayF have to agree with you on every aspect Mounjaro has been a game changer for although I am on 15mg I was started on 10 mg then 12.5 and noticed differences in my bloods and minor weight loss been on 15mg for 3 months now hab1c is now 48 (4.8) toujeo now at 158 from 220 and novarapid morning lunchtime dinnertime are all reducing plus the low carb diet is working great I plan all my meals using nutracheck excellent app keep up the good work your doing great
 
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