Non insulin/exercise related blood glucose drop. I need help.

Hi,

I've been a T1 diabetic for 3 years now, I'm active and in all likelyhood experiencing an extended honeymoon. Currently eating 80g of Carbs a day.

At around 5pm, when I'm standing up to leave work my blood glucose is dropping extremely rapidly and at around 4-5mmol in as little as 2-5 minutes.

I've been speaking to my Endio, who is going through the very same ABC steps that I've already taken, removing exercise/insulin/suppliments from the list of culprits. In the meantime I'm having rerally bad Hypo's down between 1-2mmol Monday to Friday. This has been happening since December and I'm sure this isn't very good for me in the short or long term.

What I've tried

• Removing insulin - For 48h I trialed not taking any insulin whatsoever, both days my sugars remained at about 9mmol, this means no nighttime basal, daytime basal or bolus for food. This caused my background glucose to rise both days to about 9mmol/l by 4:55pm. I still dropped to about 4mmol/l on both days.
• Stopping exercise - The following week I didn't exercise at all. My numbers at 4:55pm were between 5-7mmol/l, my last bolus at 12:30 (2 units for lunch). I dropped to 1.9 then 2.2mmol the next day.
• Stopping suppliments - I take Q10. Vit C, D, Fish Oil, Calcium/MAgnesium, Plant sterols, Acidophilus and Choline daily. For 1 week I stopped tkaing these suppliments. My numbers reacted the same as removing exercise, I still dropped 4-5mmol at 5pm.
• Increasing my lunchtime calories - For 1 week I ate more protein, fat and carbs to increase my lunchtime meal. Other than needing to increae my lunchtime bolus, my numbers still dropped an equal amount as usual 4-5mmol.

I'm pretty sure my Endio is going to sequentially go through the same steps as he's pretty odd about trusting that I've already tried these things. He says my thyroid at last check was okay, also that I only has a small marker show up for Celiac that then showed up negative on a followup. My Adrenal response is normal apparently also ruling out Addisons.

Is there anything anyone can think of that might be attributing to this drop, because the only thing I'm able to do is repeatedly attempt to offset the drop by eating a tonne of rapid carbs with varying success at about 4:45 which is only dealing with the symptom, not the cause.

The only thing that even approaches a solution is that this doesn't appear to be happening at the weekend. So perhaps an inactive day is doing something. I'm not storing injected insulin, but maybe I'm storing my background honeymoon insulin, since this works efficeintly enough to represent the drop, but doesn't exaplin why at 5pm and why its being stored and dumped when it;s not needed.

I drink a couple of cups of Coffee in the morning, nothing in the PM other than Lemon and Ginger tea, I have soup at lunch which tops out at around 20g of carbs so I only take a couple of units tops.

The only difference between my job and the weekend is the amount of activity I undertake, as I have a desk job. Under advice from my Endio, last week I didn't take any rapid acting insulin apart from a shot to lower Dawn phenomenon. After lunch my numbers spiked, returned to normal and continued to drop slowly until 4:30 when they rapidly started to drop. (See the graph below of a typical day, ignore the morning low I overestimated my dawn phenomenon correction). My Endio wants me to stop all insulin next week and do a record like the chart below again, he also said that in rare cases the body tries to re-grow beta cells and in some cases this is more successful than it should be, the beta cells regrowth outstrip the beta cell destruction by the antibodies. I don't know what to make of that, it sounds like bunk. It's not like I'm cured.