postprandial endotoxemia

finsit said:

high fat diet?

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Do you eat a high fat diet? Personally I think my diet of real food contains just the right amount of natural fats that humans have evolved to eat.

I think like most nutritional questions this is hard to unravel:
Endotoxins are released when bacteria die, and then dissociated endotoxins are able to cross the gastro-intestinal barrier to end up in the bloodstream. The presence of LPS in the bloodstream is defined as endotoxemia.
I then googled symptoms which seem rather vague e.g. lassitude, anxiety and depressive ones.
What foods cause endotoxemia
Diets with large amounts of saturated fat, animal products, and refined carbohydrate may induce endotoxemia more markedly than diets containing fiber-rich plant-based food.

From this I note the words fat and refined carbs (i.e. junk food) and 'may' induce....

I am more inclined to think that preventing high insulin and high glucose levels via a 'real food' non ultra processed food diet that has served us well evolutionarily is likely to be a good bet. Adding in butter and MCT to your coffee or eating fat bombs seems unnecessary unless you are attempting to follow a ketogenic diet for clinical reasons but have never head of this causing the issue you raise here.
but thanks and i will check out the Youtube and try to keep an open mind.

LPS is apparently a normal activity that protects us from bacterial infection. LPS is not the traditional endotoxins that are harmful such as e.coli but is now been added to the class as an endotoxin because it is comprised of external antigens that trigger the immune system. The application of the term toxin is a misnomer and I suspect it is science trying to bend animal products into demonic forms so they can be blamed once again
https://en.wikipedia.org/wiki/Lipopolysaccharide

The OP asked a question - should we be reducing the saturated fat content of our diet?

To answer that we need to understand how our bodies metabolise fats. Most people think that "Fat which we eat" = "Fat which we store ". Simple equation and simply wrong!

Our bosy runs a very efficient and effective cut and shut operation. Everything we eat gets stripped down to its underwear , then welded together in forms that our body and RNA code controls so that what gets stored is recognisable by our immune system,. i.e. becomes coded specific to us. So carbs get gutted till there is only glucose left. Fats get chopped up into smaller bits and then our body synthesises these bits into fatty acids and proteins. Some fatty acids are Saturated Fatty Acids (SFA) because this is the most efficient form for storage and also for burning for energy as ATP. This is why animals manufacture saturated fat, and we get butter and lard and cheese from them. We are animals too. So the only benefit from eating saturated fat is that it is nutrient dense, and we expend less energy making the components we need to synthesize. But even if you do not ever eat saturated fat, your body will be full of SFA.

The other point is that when fat is extracted from the gut, it is at that point alien to us, and would be attacked by the immune system. so our body wraps these fats into a bubble called a chylomicron, which is a supertsnker version of LDL, and this carries the fats etc direct to the liver for processing.The liver then produces LDL containing processed fats for storage in the adipose tissue. So the link between eating fats and LDL is not direct, but indirect.