Prediabetes are genetic variants

Hi

I am not a diabetic but I was diagnosed as a prediabetic in a 1964 glucose tolerance test (70, 1/2 hr 130, 1 hr 175 , 2 hr 185 , extended 3 hr 100). I have a relative who was declared to be sure they would have diabetes in 2 years over 30 years ago (no problem). There was a weight loss doctor on PBS (public television) who said he took GTT (why?) of his patients (couldn't figure out why some did not lose weight) and said that about 10% of his patients were prediabetic and they did not lose weight on his weight lose program. He called it the hunter gene. Due to other problems I am on a severe Atkins diet. I do not lose weight without the normal struggle. People with prediabetes have a gene (may be several) which stops them from processing sugar until there blood sugar rises. This is very good in famines and with an Atkins style diet. The reason everyone doesn't have these genes is partially that it makes you more susceptible to diabetes (unless you have lucky genetics like me).

No. Why should I? I have had no problem of that type for as long as I can remember. I have never had a high A1C (maybe low 1 year). I have never had a high fasting blood sugar. This is also true of my relative (with a caveat if you insist I can ask if I can tell) who had such a bad GTT that the doctors said they would have diabetes for sure within 2 years.

I just watched the great Randy. If you think I am an imposter check
out my theory. That is all I want in any case. See what fraction of
the population is prediabetic with no other symptoms (me for 77 years or
from at least from 1964). Is it close to the 10% as the diet doctor
reported or less because he was a fake and/or he had a biased population
(people who wanted to lose weight). Try an Atkins diet on some random
prediabetics (I may have lost weight for something like a year until my
present state but I was an exercise freak, I am cutting back the
calories and upping the exercise with hope). I am fat. Just to make
things interesting all of Someville Hospital's records (my GTT) have
been destroyed. I checked with Joslin Diabetes Clinic and Dr Barnett
and my records of our meeting in 1964 seems to have disappeared. If you
interview my wife before she dies she can corroborate much of what I
say. Maybe the Massachusetts General Hospital still has a record of
when I did not know what was wrong with me (doubt it about 1960). I
have bought 2 ads in the N.Y. Times read them. They explain why I
can't take another GTT.

Galja said:

You can BUY A1C test, a glucose monitor and you can see whether you react one way or another high or low to food.

Notk going on an Atkins diet because I don't think I will have some of the micronutrients I need

Click to expand...

Galja said:

You can BUY A1C test, a glucose monitor and you can see whether you react one way or another high or low to food.

Notk going on an Atkins diet because I don't think I will have some of the micronutrients I need

Click to expand...

Hi

My self diagnosis (I do not exist in the medical literature) is that I have a gene which is good in famines (diet doctor on T.V. found this out, of course this leads to other problems) which does not process sugar immediately but waits for the blood sugar to rise. One of the problems is that you can get an autoimmune disease where one type of cell in your adrenal glands is destroyed and the necessary timing is fouled up (don't know but I guess this is a rare problem). Another major problem is that all the sugar problems related to pregnancy are most likely found from this gene. I can only hope that the low carb vegetables I now eat supply the micornutrients otherwise I am subject to (my description) 1/3 the symptoms of a bad case of chronic fatigue syndrome. My A1C and fasting blood sugar are fine (no need for monitoring).

Neil

yetta2mymom said:

Hi

My self diagnosis (I do not exist in the medical literature) is that I have a gene which is good in famines (diet doctor on T.V. found this out, of course this leads to other problems) which does not process sugar immediately but waits for the blood sugar to rise. One of the problems is that you can get an autoimmune disease where one type of cell in your adrenal glands is destroyed and the necessary timing is fouled up (don't know but I guess this is a rare problem). Another major problem is that all the sugar problems related to pregnancy are most likely found from this gene. I can only hope that the low carb vegetables I now eat supply the micornutrients otherwise I am subject to (my description) 1/3 the symptoms of a bad case of chronic fatigue syndrome. My A1C and fasting blood sugar are fine (no need for monitoring).

Neil

Click to expand...

Hi

What do you think of this too long ad (how can I edit?,does it sound good?).


Of interest? I would help support a study ($) of what women’s GTT (glucose tolerance test) was before pregnancy. I would help support a study ($) of what the actual GTT of people with normal A1C is. Why?


I have the following facts.

My GTT 1964 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100 (diagnosis prediabetic assumed insulin resistant). I have never had a high A1C or fasting blood sugar. A relative was informed that they were sure to become a diabetic in 2 years or less over 30 years ago (still going strong). A weight loss doctor (PBS, 2015) drew my type GTT and said these people (about 1/10 of his volunteers) did not lose weight on his weight loss program. He called it the hunter gene (anyone know his name?). I do not lose weight on an Atkins style diet.

My theory 2 separate conditions: Some people who have been called prediabetics actually have a gene(s) which leads them to postpone processing sugar until their blood sugar rises (what this means is unknown). This would be good in famines and if you eat an Atkins style diet.

I assume there are at least 2 problems with this gene. One problem (why it is not prevalent) is that women can have sugar problems during pregnancy and can lose their baby and possibly their life. The second problem is there is an autoimmune disease (one cell in the adrenal glands is destroyed) which compromises the (complicated?) chemistry which allows the body to only start processing sugar when the blood sugar rises.

I wish to help fund a study that follows the glucose tolerance tests (GTT) of women before, during and after pregnancy. The major reason for this study is that a doctor on PBS in 2015 drew two graphs of a GTT. GTT’s run for 2 hours. The first GTT went up and then down. He indicated this is the expected GTT. The second GTT slowed its rate of assent but was still rising as he lifted his marker. The second is my GTT (1) taken in 1964. Does anyone know the name of this doctor? He defined such people as having a hunter gene. He said people with this GTT did not lose weight on his weight lose diet. Since people with the hunter gene should be better able to survive famines there must be a downside to this gene. I guess the downside is that women with this gene have problems controlling their blood sugar during pregnancy. I have the following question, assume a woman has sugar problems during pregnancy. How can you see if her GTT has returned to normal after pregnancy if you don’t know what is her normal GTT? I have the following observation if women with the hunter gene are much more susceptible to sugar problems during pregnancy maybe you can explore possible pre pregnancy interventions with these women.

In 1964 a doctor looked at my GTT and said I was prediabetic and was developing insulin resistance. I have not become diabetic. A second reason for this ad is that the reason for my GTT in 1964 is that I get low blood sugar many hours after eating too much sugar/starch/alcohol. I know of 3 other people with the hunter gene who also have this symptom. We also have other symptoms which I describe as a fraction of the symptoms of a bad case of chronic fatigue syndrome. These symptoms are controlled by never letting our blood sugar go above an unknown value.

I theorize that the hunter gene allows people to only store sugar when their blood sugar rises above some value. I have reason to believe I had an episode which was an autoimmune reaction. I therefore theorize that doctors should be aware that it is possible for people with the hunter gene to have one type cell of their adrenal glands destroyed which compromises the possibly complicated chemistry that allows them to store sugar based on their blood sugar. Doctors should advise people with the reactive hypoglycemia and GTT I have described that they will feel better if they carefully control the sugar/starch/alcohol in their diet (2).

(1) GTT 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100.

(2) I eat an Atkins diet. Another patient posts he/she feels fine with a diet which includes slowly absorbing starch.