Found this on Rotherham PCT knowledge base:
Glucosamine and Diabetes
In 2006 the Medicines Information Service looked at the interaction between Glucosamine and Diabetes and found that:
“Research from animal studies suggests that high-dose intravenous (but not oral) glucosamine may interfere with blood glucose control. Similar effects have not been consistently documented in humans. A review of the literature found only one placebo-controlled double-blind trial that assessed the effect of glucosamine in patients with diabetes mellitus. In this study, patients with type 2 diabetes who were not receiving insulin were randomised to receive glucosamine 1,500mg plus chondroitin 1,200mg daily (n=26), or placebo (n=12) for 90 days. HbA1c values increased slightly (0.05%) in the active treatment group and decreased slightly in the placebo group (0.16%). These changes did not reach statistical significance. The patients in this study had well-controlled type 2 diabetes (baseline HbA1c <6.5%) and were taking a median of one oral hypoglycaemic agent. It is unclear whether these results would apply to patients with less well-controlled disease, or to those with type 1 diabetes. As the effect of glucosamine in patients with diabetes is not well studied it has been suggested that patients with diabetes should monitor their blood glucose levels more closely if glucosamine is initiated, the dose is increased or the product being taken is changed. 5
A systematic review of glucosamine undertaken in 2005 reported:
“Hypoglycemic Agents: The effect of glucosamine on glucose levels or insulin resistance has been controversial, and it remains unclear if interactions with agents possessing glycemic properties may occur. Despite initial concerns about use in diabetic patients based largely on in vitro and rat studies noting insulin resistance and possible glycemic effects and preliminary human work, more recent human research reports no significant effects (including on hemoglobin A1c levels in patients with type 2 diabetes after 90 days of therapy). Clinically relevant effects on blood sugars have not been noted in several clinical trials.” 6
5. Glucosamine – drug interactions, Medicines Information Service, 28th September 2006
http://www.druginfozone.nhs.uk/Record%2 ... ?id=577584
6. Ulbricht C et al. An Evidence-based Systemic Review of Glucosamine Conducted by the Natural Standard Research Collaboration. Journal of Complementary and Integrative Medicine Volume 2, Issue 1 2005 Article 1 (
http://www.bepress.com/cgi/viewcontent. ... ntext=jcim).
So no real evidence of a negative impact on BG, sadly the report also indicates that glucosamine only provides a marginal positive impact on joint health too! Might just ditch that one then!