Not sure if you're from the UK or not but here serum creatinine is considered to be an unreliable marker of kidney function with eGFR being accepted as the best marker to establish and monitor a patients renal function. The calculation takes into account variables which a standard creatinine doesn't.The GFR refers to the "glomerular filtration rate" and is a simple calculation based on your serum creatinine (blood test), your weight, maybe age. It refers to kidney funtion. The serum creatinine is the key element (usually around 1.0 in the US). I wouldn't get to wrapped up in the GFR if I were you. I've never looked at it in any patient I've treated. I just look at the creatinine.
So doctors there rely on the GFR not the serum creatinine? I feel sorry for them, because in order to do a proper creatinine clearance without utilizing the serum creatinine it requires the patient submit a urine sample usually comprising 24 hours. We ain't got time for that over here lol. Remember if, as you say, the serum creatinine "is considered to be an unreliable marker of kidney function" then it must not be utilized in any fashion in the method that replaces it. Otherwise its assumed errors would be baked into the GFR that's derived from it. In my prior post I did point out what's probably factored into the simple GFR that we use.Not sure if you're from the UK or not but here serum creatinine is considered to be an unreliable marker of kidney function with eGFR being accepted as the best marker to establish and monitor a patients renal function. The calculation takes into account variables which a standard creatinine doesn't.
We use both here, my point in answer to yours was that we would.never rely just on serum creatinine as you said you Did, because here eGFR is considered to be a superior marker of kidney function. 24 hr creatinine clearance is rarely done here now, used to be commonplace about 15 years ago.So doctors there rely on the GFR not the serum creatinine? I feel sorry for them, because in order to do a proper creatinine clearance without utilizing the serum creatinine it requires the patient submit a urine sample usually comprising 24 hours. We ain't got time for that over here lol. Remember if, as you say, the serum creatinine "is considered to be an unreliable marker of kidney function" then it must not be utilized in any fashion in the method that replaces it. Otherwise its assumed errors would be baked into the GFR that's derived from it. In my prior post I did point out what's probably factored into the simple GFR that we use.
For example: many times the PCP will prescribe a low dose of lisinopril (and ACE inhibitor) to a Type 2 diabetic as in some cases it can lessen the effects of diabetes on renal function or microalbuminuria. But if their creatinine is already borderline they'll certainly want to recheck it and make sure it doesn't go up as well as the serum potassium. Here at the VA we have what is perhaps the oldest continuous use electronic medical records systems (called CPRS) in the world. You can find vets' lab results from WAY back there, probably to 2000, from any VA facility in the country.Often in the UK, there is no history of creatinine tests result, hence a GP has to decide what drugs are safe based on a single set of blood tests. (However, there should be a history of test results for anyone with Type2.) I think GFR cutoff are given in the prescribing guidelines.
For some reason, doctors in the UK don't look at changes in test results as much as the current set of results. When looking at my own results, I care more about the shape of the graph, then absolute values, but this may be because I have been trained in complex systems and that is how engineers tend to think.
Often in the UK, there is no history of creatinine tests result, hence a GP has to decide what drugs are safe based on a single set of blood tests.
We regard a bump in the creatinine from 1.2 to 1.4 to be significant,
Mg/dl is what we use. Blood sugar normal is 60-110. We take your number and multiply times 18. Different for creat. Ours is 0.7-1.1 I think.Which measurement units are these? In the UK it is umol/L and the standard range on my lab reports is 46 to 92.
Mg/dl is what we use. Blood sugar normal is 60-110. We take your number and multiply times 18. Different for creat. Ours is 0.7-1.1 I think.
I believe the measurements we use for serum chemistry items are mg/dl. There's a conversion table somewhere out there.I wasn't meaning units for blood sugar levels, I meant units for serum creatinine. You mentioned figures such as 1, 1.2 and 1.4. They don't relate to our range of 46 to 92umol/l
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