paragliderpete
Well-Known Member
- Messages
- 179
Hi All.
I've been investigating the causes of insulin resistance recently, in an attempt to try and improve mine. In the process I've discovered a distinct link between the adrenal gland function, in particlular cortisols actions and our blood glucose level. Much of which we appear to have little control.
The net metabolic action of cortisol is to raise circulating free fatty acids and glucose, the latter stimulating glycogen synthesis. This in turn creates a phenotype of " insulin resistance", creating an increased need for insulin secretion to maintain normal blood glucose levels.
Cortisol increases blodd glucose levels by promoting gluconeogenisis, raising hepatic glucose output, and inhibiting glucose uptake by mucle and fat (insulin resistance), whilst at the same time inhibiting insulins ability to regulate hepatic glucose output.
( out of control glucose generation) at the same time failing to supress lipolysis in adipose tissue resulting in raised triglyceride levels. It similarly elevates total and ldl cholesterol, and lowers hdl levels.
Serum cortisol varies diurnaly, with maximum level occuring in the early morning, and produces similar grphical profiles to that of the morning effect, and could well explain why medication and diet have little effect on this phenomenon. Indeed some of the belief in liver dumps being due to bm levels could well be a cortisol effect.
Some symptoms of excess glucorticoid include muscle wasting, visceral fat, central obesity, and slow healing of wounds/ infections. It does appear that increased cortisol levels may be playing a part in preventing the normalisation of insulin resistance, and fully normalising blood glucose level. I do not believe to cortisol level however to be excessive which would suggest cushings syndrome. A sort of pre diabetic state.
It seems to me that cortisol could be well be having a significant effect on our diabetic condition and subsequent control. Medical solution seems to be control of the symptoms by metformin, rather than addressing the cause.
Has anyone else any experience in this area, I would appreciate any views and thoughts , in particular any ideas how I might establish how much of an effect cortrisol is having, and what can be done to minimise it effects
I've been investigating the causes of insulin resistance recently, in an attempt to try and improve mine. In the process I've discovered a distinct link between the adrenal gland function, in particlular cortisols actions and our blood glucose level. Much of which we appear to have little control.
The net metabolic action of cortisol is to raise circulating free fatty acids and glucose, the latter stimulating glycogen synthesis. This in turn creates a phenotype of " insulin resistance", creating an increased need for insulin secretion to maintain normal blood glucose levels.
Cortisol increases blodd glucose levels by promoting gluconeogenisis, raising hepatic glucose output, and inhibiting glucose uptake by mucle and fat (insulin resistance), whilst at the same time inhibiting insulins ability to regulate hepatic glucose output.
( out of control glucose generation) at the same time failing to supress lipolysis in adipose tissue resulting in raised triglyceride levels. It similarly elevates total and ldl cholesterol, and lowers hdl levels.
Serum cortisol varies diurnaly, with maximum level occuring in the early morning, and produces similar grphical profiles to that of the morning effect, and could well explain why medication and diet have little effect on this phenomenon. Indeed some of the belief in liver dumps being due to bm levels could well be a cortisol effect.
Some symptoms of excess glucorticoid include muscle wasting, visceral fat, central obesity, and slow healing of wounds/ infections. It does appear that increased cortisol levels may be playing a part in preventing the normalisation of insulin resistance, and fully normalising blood glucose level. I do not believe to cortisol level however to be excessive which would suggest cushings syndrome. A sort of pre diabetic state.
It seems to me that cortisol could be well be having a significant effect on our diabetic condition and subsequent control. Medical solution seems to be control of the symptoms by metformin, rather than addressing the cause.
Has anyone else any experience in this area, I would appreciate any views and thoughts , in particular any ideas how I might establish how much of an effect cortrisol is having, and what can be done to minimise it effects