Spiker
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- Type of diabetes
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Simples!
Simples!A sort of comparethefruitfly.com
Yes, they do take anti rejection drugs. At five years though only 7.5% of islet transplant patients are off insulin but most still make some C peptide showing that some islets are still working There are also a number (smaller but I don't have the figure) whose bodies completely kill off the new cells within that period.
(This is info from the Coursera Global diabetes course; the researcher/lecturer works at the Novo Nordisk laboratories.(!)
There appear to be progenitor cells in the pancreas which may be able to become new working islet cells.
Until recently it was thought that in non diabetics cells in the pancreas were like neurons and simply died off with age and were not replaced . It was thought that cells were replaced very slowly by division and those that were killed off by gluco/lipotoxicity or autoimmune attack were could not be replaced since completely new cells were not formed after childhood/adolescence.
However in mouse models they have been able to show that new cells were 'grown' in a damaged pancreas. http://www.betacell.org/content/articleview/article_id/114/
There are other studies that seem to support this view (not completely unchallenged though).
It is also known that initially the beta cell mass increases in those that become obese (that's why all overweight people don't become diabetic) Indeed beta cell mass increases during normal pregnancy. This means that there must be either new cells formed or increased cell division and some sort of signals in the body that causes this to take place.
They have also discovered that very long term Type 1s have some insulin producing islets (very small amounts that couldn't be detected by earlier techniques)
However, the autoimmune 'attack' may continue as has been demonstrated in islet cell replacement therapies, one theory is that cells may be produced and then killed off continuously. What is clear is that the process is very slow and doesn't provide very large numbers of new cells.
(that's why an important field of research is how to encapsulate and protect implanted cells to stop them from just being killed off again)
How to reprogram progenitor cell to increase functional beta cell mass is very much a target of international research.
These are the aims of the 'beta cell consortium'
http://www.betacell.org/research/
- Use cues from pancreatic development to directly differentiate pancreatic beta cells and islets from stem/progenitor cells for use in cell-replacement therapies for diabetes,
- Determine how to stimulate beta cell regeneration in the adult pancreas as a basis for improving beta cell mass in diabetic patients,
- Determine how to reprogram progenitor/adult cells into pancreatic beta-cells both in-vitro and in-vivo as a mean for developing cell-replacement therapies for diabetes, and
- Investigate the progression of human type-1 diabetes using patient-derived cells and tissues transplanted in humanized mouse models.
Stem cells research is not done on humans to begin with thus flies (of the type Drosophila) are very commonly used. What they want to do is to uncover general mechanisms controlling stem cells. They look at their differentiated daughter cells to get some idea about what is happening when these cells become specialized. They are looking at genetics to investigate the cell biology, in this case of the intestine.
Hmm maybe this is a bit esoteric.
If you are interested to begin a dialogue you need to do one thing first and that is to satisfy your self that mental suggestion is a reality. Then you can examine your thoughts and ideas in a new light.
From Louise Hay’s “Heal Your Body”:
“Diabetes (Hyperglycemia, Mellitus)
Probable Cause: Longing for what might have been. A great need to control. Deep sorrow. No sweetness left.
Affirmation: This moment is filled with joy. I now choose to experience the sweetness of today.
DE-MISTIFYING THE PANCREAS (sic )
Imagine if you could actually plug yourself into a main computer; you’d be able to listen in and discover how the interplay of emotions and feelings affect every cell and organ of your body. Today we’re going to zoom into the pancreas and discover what could cause low blood sugar or diabetes.
The pancreas’ main function is to assist in transforming and transporting foods and fluid throughout the body, purifying the blood and chi (lifeforce/energy) in the body. So the pancreas has a nurturing, nourishing energy about it.
In Chinese Medicine, the pancreas is paired with the Spleen Meridian. This meridian is feminine (Yin); its element is Earth, relating this body-centered organ to the archetypical Mother.
For most of us our mother was the first encounter we had with being nurtured and loved, we were dependant on her care. Constantly we had to watch, anticipate and respond to her needs and wants, trying our best to make her happy. What an emotional rollercoaster! A smile or a frown can change our perception that the world is safe or dangerous. And we carried these emotions, these feelings and our ways of coping with them all through our life.
The brain is the first to record traumatic events and experiences. When the brain can’t handle the excess stress it passes it on to an organ in the body, which immediately records the emotion.
The need to be loved is a secret hunger for the Pancreas. Eating is a social act that has deep emotional meanings. Early in life food somehow got mixed up with love and caring — we started eating because we felt undernourished and/or didn’t get enough nurturing. There are also some of us who eat to feed the hungers caused by stress or loneliness. All this has an impact on our pancreas, affecting our energy, our attitudes and blocking our metabolism.
When a mother/parent is emotionally distant, the child soon learns to keep his/her own distance as well. Rejection from a parent can lead to a child rejecting the parent which can lead to rejecting his/her own life-force. To survive, he/she numbs their body, numbs their feelings, constricting and minimizing their life energy. Holding it in, they look and appear independent, others admire their independence, but they are virtually alone in their own world, determined to avoid, at all costs, being vulnerable to rejection.
The Pancreas is also extremely vulnerable to intense emotions and feelings caused by a reaction to an outer event. In fact both the spleen and pancreas react to serious events that can affect us for life. These two organs absorb most of our severe shocks.
Emotional shocks felt physically and emotionally by the body are recorded by the unconscious mind in two-thousandths of a second! Physically we can dress and heal our outer wounds but the memories of the trauma become imprinted in the unconscious mind. When something or someone triggers that memory, it resurfaces activating a rush of adrenalin, fear and stress in our lives.
THE PLANET VENUS
This leads us to Astrology, especially the planet Venus. Venus rules the secretion of insulin, the assimilation of sugars and carbohydrates in the body. She also rules the saliva in relation to digestion, the swallowing reflex as well as the our sense of taste, touch and smell.
DIABETES: Mental Attitude: Refusing to give. Takes the form of deliberately withholding Self from others. Fear of never being able to have enough. Thinking Self does not have enough to give, therefore being stingy with how one gives.
Suggestions for Improvement: Be courageous. You can’t hide your Self forever, and fear is a limitation. Bring the real you out where others can see you. You may find you are a pretty valuable person. Practice giving something away every day to a stranger. It must be a stranger so you will not expect something from them in return. Choose to give to someone you will not see again. This is a place to begin.
Pancreas
Mental Attitude: Desire to give and holding back on this. Fear of losing from giving. Attitude of Self righteousness which is selfishness. Conditionally giving and receiving. Jealousy.
Suggestions for Improvement: Have the courage to reveal the Real you. Give to ten people each day. Find a present for someone each week, a present that is very special and just exactly for that person.
Are you willing to do an investigatory journey?
you aren't trying to promote a money making con, so I don't have too much of a problem with a dubious far fringe theory, that most will rightfully dismiss.The avenues explored in the lab involve methods that will ultimately make money for the researches and the drug companies. It is understandable. But the body is the ultimate healer.
If I could give you a solution simply in a few words I would but I can't. Your input in your recovery is what is important.
If you are interested to begin a dialogue you need to do one thing first and that is to satisfy your self that mental suggestion is a reality. Then you can examine your thoughts and ideas in a new light.
About half way down this page
http://www.diabetes.co.uk/forum/threads/is-type-1-reversible.58248/page-3
I gave two experiments that a person can do to satisfy themselves about mental perceptions.
Once you have done that you need to then begin to understand how your thoughts, or what you have believed are your thoughts, i.e., of your own creation and see what there is that may involve the problem of your immune system attacking your beta cells. It appears from the research that I am right in saying that the body does produce beta cells from the stem cells in the pancreas but they are being destroyed as they are being made. You need to draw a halt to this process.
I strongly suspect that it is along the same lines as cancer but with a different effect. In cancer the immune reaction is to build a cell barrier for protection.. a bad solution but it is what the person thinks might help. In autoimmune disease the immune system attacks an area it sees as dangerous or of danger to the person's overall safety or as having been damaged so an inflammatory response is initiated and it's unnecessary..
The one thing that I found that stops cancer and begin remission if any cancer has started to develop is to realize that the ideas are bogus and that any danger as may be perceived is external. Once the danger is seen to be external the immune system halts its over reaction or may even go into low reactivity. So the problem is arrested.
Are you willing to do an investigatory journey?
you aren't trying to promote a money making con, so I don't have too much of a problem with a dubious far fringe theory, that most will rightfully dismiss.
perhaps it's because I don't have the intellect, I'm using most of my brain power remembering to breathe
I wonder if that could be an explanation for my still quite low doses.Have a look at ketosis prone T2 diabetes (AKA , type 1b or idiopathic T1 or Flatbush dietbets)
This was first found in Black Americans and is relatively common in them however it has been found in most other ethnic groups.
Short definition here (unfortunately have to subscribe for more detail)
(edit, most though, but not all seem to be more likely to be overweight )
http://www.uptodate.com/contents/syndromes-of-ketosis-prone-diabetes-mellitus
Papers on it here
http://www.ncbi.nlm.nih.gov/pubmed/22611441
LADA as mentioned by Ali H is also a possibility. . I've certainly seen some people on forums who had DKA at diagnosis reduce insulin and even stop taking background insulin for a while, just keeping small amounts of rapid for mealtimes. I think that probably, once the glucose toxicity is reduced there are enough beta cells still working to allow almost normal function for a while,
The defining characterisitic of LADA is being antibody positive (those with KPT2 of T1b are antibody negative)
http://www.diabetesmine.com/2010/03/clarifying-lada-type-1-diabetes-in-adults.html
Kyrani, you may not be trying to charge money (yet), but you are still selling something.
Yes Signy, it's straight out of Louise Hay, only with none of Louise Hay's positivity. It's like if Louise Hay went over to the dark side.
I wonder if that could be an explanation for my still quite low doses.
Today was quite exceptional with a 3hr30 bike ride, but that was done on just 1U basal. I've also previously had my BG go from 7.2 to 12.2 and then back to 7.2 in 4 hours with a 45g carbs load and 1U basal.
I'm still on 1:15g for bolus 15months down the line and am averaging <15U total insulin per day.
Thanks for posting those links.
EDIT - reading again probably not, as I think I was GAD positive on diagnosis
I don't think I'll get that image out of my head, it gives a whole new meaning to SupercalifragilisticexpialidociousNow that is a truly 'orrible mental visual !
Sorta like imagining Julie Andrews as a dominatrix .
Signy
In fairness Julie Andrews appeared topless in the 1981 Blake Edwards film S.O.B.I don't think I'll get that image out of my head, it gives a whole new meaning to Supercalifragilisticexpialidocious
Sorta like imagining Julie Andrews as a dominatrix .
Signy
Kyrani, you may not be trying to charge money (yet), but you are still selling something.
Yes Signy, it's straight out of Louise Hay, only with none of Louise Hay's positivity. It's like if Louise Hay went over to the dark side.
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