Hi, I started looking for Metformin before I got it on prescription. So bought a tub of 240.....and 1 500mg 3 times a day is max dose. I've been started on similar dose of Metformin, hence only one of each.....I was on max does of metformin before 3000 mg per day. So only on the berberine until it runs out. I was diagnosed with Type 2 in 2010, but suspect I had the condition many years before as used to go to the loo like a yo yo. When I say full blown, I meant Type 1, pancreas producing no or very little insulin. I will continue to monitor the situation, but have no hopes for a reversal of the condition....but if I could take less insulin where metformin works, then great.