Ideally, in the future we will have results on CVD and mortality risk from a large randomized controlled trial pitting a well-formulated ketogenic diet against the best that usual care can offer. In the interim, we have demonstrated that a continuous care treatment including nutritional ketosis in patients with type 2 diabetes improved most biomarkers of CVD risk after one year. The increase in LDL-cholesterol appeared limited to the large LDL sub-fraction; whereas LDL particle size increased, total LDL-P and ApoB were unchanged, and inflammation and blood pressure decreased.