I agree there is a distinctive taste to the tablet. I am 2 weeks into the randomisation and I still have this taste, my appetite has not returned and still have acid reflux so I think I am on the real thing.
Do they keep on changing the meds so sometimes you get the semiglutide and other times the placebo or are you kept on the same throughout the trial. I did read that the trial could last for 5 years2 weeks into the Randomised tablets.
I think I am on Semaglutide, not the placebo.
Lost another 1kg in weight.
Appetite is still suppressed.
An hour after taking the tablet, can't face a morning cuppa or toast (feelings of nausea) so it isn't until late morning or early afternoon before I have a snack.
I will see what my BG levels are in a few months, when I request a blood test, and if still dropping will seek a medication review to reduce my Metformin dosage and/or stop the sitagliptin.
I believe once you start on the randomised tablets, you will stay on whatever you were given (either Semaglutide or the placebo) as otherwise they cannot measure the outcome of the trial.Do they keep on changing the meds so sometimes you get the semiglutide and other times the placebo or are you kept on the same throughout the trial. I did read that the trial could last for 5 years
Are these the randomisation tablets?It seems strange. The last bottle I took didn't seem to do anything. Yet the bottle this month bloods dropped more and have lost a little more.
Yes they are. Nearly at the end of the first box....Are these the randomisation tablets?
If so, I think you may be on the Semaglutide and not the placebo, and your body may just be settling into the medication.
I have had a quick look at the trial documentation, and it confirms that once you start the randomisation stage, you will remain in the same (Semaglutide or placebo) for the rest of the trial.
I attach a copy of the PIL, paragraph 3 on page 13 is where I got the information from (web link for the downladable document is https://www.ascend-plus-trial.org/files/ascend-plus-pil_full-a4_v-1-3_rgb-for-web.pdf)
Hope that helps, your results look promising.
I''m sorry your mum's had a stroke @theresaxx . I hope it's a mild one, and she recovers well. Take care of yourself. Sending virtual hugs xxWell into 1st bottle randomised tablets, no bitter taste blood glucose levels creeping up slowly but I am stressed as my mum has had a stroke and I did have a couple of days eating things I shouldn’t (son’s 30th)
I think I am on placebo but hoping that the above reasons are causing the increase sugar levels.
Hope everyone is doing well
Hi I started it on it and have just reached the stage where they have sent me 6mths supply of 14mg. I havent lost any weight, not noticed any changes to my readings. The only thing i felt was full. I have started taking the 14mg today and believe i may be on the placebo, purely based on taste, the initial tablets are bitter, the one I took today is tasteless. If i am on the placebo I am very disappointed, was looking for reduced readings and of course weight loss?Just thought aid start a discussion here for anyone on the Ascend Plus trial by Oxford University.
Started my “Run In” phase yesterday and so far so good. No side affects other than fatigue. How are other folks doing?
I am interested in responses as just started taking the 6mth supply and I too noticed that the new tablet, 14mg, is tasteless, like you noted the initial tablets were bitter?Hi. I'm about 2 weeks into the randomisation and convinced I am taking the placebo. Did anyone else notice a difference in the taste of their run-in drug compared with their randomisation drug? I found the actual semaglutide tablet that I took during the run-in was very bitter on my tongue when swallowing. The randomised drug I'm taking now has no such taste and is completely bland which is why I am sure it must be the placebo. What have other people experienced in regards to the taste?
does you 14mg tablet taste bitter or tasteless, mine are tasteless and convinced on the placebo, does anyone know better?Well I thought I wasn't on the placebo but now at the end of first box of proper trial tablets. Now all symptoms gone and not losing weight.
will you carry on? I am gutted not on the real thingMine are tasteless I think I am on placebo.