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Are fats the direct cause of insulin resistance?
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<blockquote data-quote="phoenix" data-source="post: 625948" data-attributes="member: 12578"><p>I think this is what is considered an important early paper in the formation of what is sometimes called lipid burden hypothesis</p><p>Lovely title</p><p><a href="http://worldtracker.org/media/library/Science/Science%20Magazine/science%20magazine%201991-1992/root/data/Science%201991-1992/pdf/1992_v258_n5083/p5083_0766.pdf" target="_blank">What If Minkowski Had Been Ageusic? An Alternative Angle on Diabetes 1992, J Denis Mc Garry. </a> </p><p> </p><p>His Banting lecture on the same subject is here <a href="http://www.medscape.com/viewarticle/424459_2" target="_blank">http://www.medscape.com/viewarticle/424459_2</a></p><p> </p><p>SInce then the thesis seems to have developed to suggest that if you are thin but also insulin resistant, this is because you have less elastic or smaller or fewer fat cells . Once full they overspill and fat has to go elsewhere. In contrast, those who become very obese but don't become insulin resistant are those that have more elastic , bigger or more fat cells so the fat stays where it should be.</p><p> </p><p> You might be interested in this study which looked at this hypothesis from a genetic point of view and concluded</p><p></p><p><a href="http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0018284&representation=PDF" target="_blank">http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0018284&representation=PDF</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 625948, member: 12578"] I think this is what is considered an important early paper in the formation of what is sometimes called lipid burden hypothesis Lovely title [URL='http://worldtracker.org/media/library/Science/Science%20Magazine/science%20magazine%201991-1992/root/data/Science%201991-1992/pdf/1992_v258_n5083/p5083_0766.pdf']What If Minkowski Had Been Ageusic? An Alternative Angle on Diabetes 1992, J Denis Mc Garry. [/URL] His Banting lecture on the same subject is here [url]http://www.medscape.com/viewarticle/424459_2[/url] SInce then the thesis seems to have developed to suggest that if you are thin but also insulin resistant, this is because you have less elastic or smaller or fewer fat cells . Once full they overspill and fat has to go elsewhere. In contrast, those who become very obese but don't become insulin resistant are those that have more elastic , bigger or more fat cells so the fat stays where it should be. You might be interested in this study which looked at this hypothesis from a genetic point of view and concluded [url]http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0018284&representation=PDF[/url] [/QUOTE]
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