re the Kendrick article
The reasons why the Pima in the US have high rates of diabetes and obesity have been the subject of study for decades.
Importantly, the Pima
as a "race" do not have high rates of diabetes, only those that are in the reservations of the US.
Their genetically identical cousins in the Sierra Mardre mountains in Mexico are not overweight and don't have a diabetes problem. They continue to eat nearer to their traditional diet (which was very high carb/fibre and much lower in fat) The diet eaten in the US reservations was very different, energy dense and nutrient poor.
There are other factors involved Far too much to go into here but this website gives a lot of information
http://diabetes.niddk.nih.gov/dm/pubs/pima/obesity/obesity.htm
traditional diet of the Pima ie in the 19th century pre diabetes
http://care.diabetesjournals.org/content/16/1/369.abstract
re fat cells and people who don't have any.ie
generalised lipodystrophy’
. The current hypothesis accepted by many researchers is similar to Dr Kendrick's explanation. The difference as he says is in the order but there is a lot more to it than he suggests.
Fat is meant to stay in adipose cells ie fat cells. That's what they are for. That's the case with the very fat Sumo or even the many people who are overweight but not diabetic.
It's when they overspill that problems arrive
Rather than explain I will quote because it's hard to summarise any more than this.
The body doesn't want that fat to overflow and be deposited elsewhere in the liver or around the pancreas because that leads to further problems .
Thorkild I A Sorensen, Professor of Metabolic and Clinical Epidemiology Faculty of Health and Medical Sciences, University of Copenhagen.( part of lecture from Coursera Global diabetes course)
This is very much the theory behind Dr Taylors research. He has been able to produce images of fat deposited around the liver and pancreas. When this is reduced and fat is back to where it should be in the fat cells then people become less insulin resistant.Just as above he suggests that people have their own individual fat thresholds.
Primer on fat storage
http://science.howstuffworks.com/life/cellular-microscopic/fat-cell2.htm