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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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<blockquote data-quote="ME_Valentijn" data-source="post: 1398014"><p>Genetically, they're only about 90% similar. They have around 2,500 more genes than humans, which is a substantial difference. And in some respects they are radically different - especially noticeable in their GI systems, and that they are herbivores. I'd consider any research into mice involving diet to be especially suspect.</p><p></p><p>But mice are popular for experimentation due to their shorter life cycle and fast reproduction, meaning that it can be a lot faster to study them, versus primates. And people are generally less bothered about torturing and killing mice in the name of science.</p><p></p><p>I did come across something very relevant to the research discussed in this thread while looking into <a href="https://en.wikipedia.org/wiki/Laboratory_mouse" target="_blank">mice as lab animals</a> - there is a <a href="https://en.wikipedia.org/wiki/NOD_mice" target="_blank">Type 1 diabetic mouse</a>. They develop autoimmunity destroying the pancreatic islets. Not all of them develop Type 1, but most of the females do. I'd be a helluva lot more impressed if someone managed to reverse that, versus transient hyperglycemia induced by an insufficient dose of a drug <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite7" alt=":p" title="Stick Out Tongue :p" loading="lazy" data-shortname=":p" /> If beta cells were actually regenerating in an autoimmune mouse, they'd most likely just get destroyed again by auto-antibodies.</p></blockquote><p></p>
[QUOTE="ME_Valentijn, post: 1398014"] Genetically, they're only about 90% similar. They have around 2,500 more genes than humans, which is a substantial difference. And in some respects they are radically different - especially noticeable in their GI systems, and that they are herbivores. I'd consider any research into mice involving diet to be especially suspect. But mice are popular for experimentation due to their shorter life cycle and fast reproduction, meaning that it can be a lot faster to study them, versus primates. And people are generally less bothered about torturing and killing mice in the name of science. I did come across something very relevant to the research discussed in this thread while looking into [URL='https://en.wikipedia.org/wiki/Laboratory_mouse']mice as lab animals[/URL] - there is a [URL='https://en.wikipedia.org/wiki/NOD_mice']Type 1 diabetic mouse[/URL]. They develop autoimmunity destroying the pancreatic islets. Not all of them develop Type 1, but most of the females do. I'd be a helluva lot more impressed if someone managed to reverse that, versus transient hyperglycemia induced by an insufficient dose of a drug :p If beta cells were actually regenerating in an autoimmune mouse, they'd most likely just get destroyed again by auto-antibodies. [/QUOTE]
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