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<blockquote data-quote="Indy51" data-source="post: 1522440" data-attributes="member: 48386"><p>An addendum. I was recently researching a drug that my respiratory specialist wants to prescribe, the major side effects of which are digestive/gastric issues. The drug is metabolised via the CYP1A2 gene/enzyme. I discovered that Nexium which I - rightly or wrongly - blame for almost all the digestive issues I have, turns out to be a CYP1A2 inducer. It is also contraindicated for use with the drug he wants me to take.</p><p></p><p>When I had my 23andme genetic results, it turns out I have a SNP in that gene that makes me a slow metaboliser of caffeine and some drugs. Given my reaction to Nexium, I suspect I should avoid all drugs that are metabolised via that pathway like the plague.</p></blockquote><p></p>
[QUOTE="Indy51, post: 1522440, member: 48386"] An addendum. I was recently researching a drug that my respiratory specialist wants to prescribe, the major side effects of which are digestive/gastric issues. The drug is metabolised via the CYP1A2 gene/enzyme. I discovered that Nexium which I - rightly or wrongly - blame for almost all the digestive issues I have, turns out to be a CYP1A2 inducer. It is also contraindicated for use with the drug he wants me to take. When I had my 23andme genetic results, it turns out I have a SNP in that gene that makes me a slow metaboliser of caffeine and some drugs. Given my reaction to Nexium, I suspect I should avoid all drugs that are metabolised via that pathway like the plague. [/QUOTE]
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