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<blockquote data-quote="Mr_Pot" data-source="post: 1611897" data-attributes="member: 216415"><p>I think I will have to wait until Xmas when I see my nephew who has actuarial training to answer question 1.</p><p></p><p>I have enlarged on your comments on question 2. below. </p><p></p><p>Assume cells live for 10 weeks and are renewed on a weekly basis rather than continuously, for simplicity…..</p><p></p><p>In a sample of blood there will be 10% of cells 1 week old, 10% of cells 2 weeks old, and so on to 10% at 10 weeks old.</p><p></p><p>Assume that the glucose level is constant for 9 of the weeks but high for 1 of the weeks; say due to high carbs on a holiday.</p><p></p><p>If the holiday was week 2 of the 10 week period, only 20% of the sample existed at that time and would have been affected. If the holiday was in week 8 then 80% of the cells in the sample existed at that time and would have been affected.</p><p></p><p>So it seems to be true that the latter weeks have more effect on HbA1c than the earlier weeks. In the example a high glucose level in week 8 would have 4 times the effect on HbA1c that the same level had in week 2.</p></blockquote><p></p>
[QUOTE="Mr_Pot, post: 1611897, member: 216415"] I think I will have to wait until Xmas when I see my nephew who has actuarial training to answer question 1. I have enlarged on your comments on question 2. below. Assume cells live for 10 weeks and are renewed on a weekly basis rather than continuously, for simplicity….. In a sample of blood there will be 10% of cells 1 week old, 10% of cells 2 weeks old, and so on to 10% at 10 weeks old. Assume that the glucose level is constant for 9 of the weeks but high for 1 of the weeks; say due to high carbs on a holiday. If the holiday was week 2 of the 10 week period, only 20% of the sample existed at that time and would have been affected. If the holiday was in week 8 then 80% of the cells in the sample existed at that time and would have been affected. So it seems to be true that the latter weeks have more effect on HbA1c than the earlier weeks. In the example a high glucose level in week 8 would have 4 times the effect on HbA1c that the same level had in week 2. [/QUOTE]
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