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<blockquote data-quote="LittleGreyCat" data-source="post: 1625905" data-attributes="member: 6467"><p>I will try and tread very carefully here.</p><p>Gliclazide works by over stimulating your pancreas to produce insulin.</p><p>As they say in Blade Runner "The light that burns twice as bright burns half as long."</p><p>So I think they are correct that in the long term your insulin production will decrease as your pancreas wears out.</p><p>What I don't understand is why there is any need to switch off Metformin if you were achieving good control using that.</p><p></p><p>Purely from my personal perspective, if I could manage just on Metformin I would be very reluctant to progress to Gliclazide. I regard that as the beginning of the slippery slope you describe above.</p><p></p><p>You say "My BG has been perfect recently but with MODY the doctors say the best treatment is gliclazide.".</p><p>It is probably worth checking around to see if this is the only route available to you.</p><p></p><p><a href="http://www.diabetes.co.uk/diabetes_mody.html" target="_blank">http://www.diabetes.co.uk/diabetes_mody.html</a> says that the most common type is due to the slow failure of your pancreas to produce enough insulin. If that has happened then Gliclazide is a logical step on the treatment path.</p><p></p><p>How were you diagnosed with MODY? Why did they even test?</p><p></p><p>You can tell I am having some mental indigestion over this.</p><p></p><p>Anyway, welcome to the forum.</p><p></p><p>You say "I'm not sure how t2 works to be honest ". Plenty of information on this site. Get stuck in and enjoy yourself <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p><p>Briefly, with T2 you are either producing enough insulin but your body is refusing to use it properly (Insulin Resistance) or your body isn't producing enough insulin (similar to MODY).</p><p></p><p>I think the difference between Type 1 (which I understand includes MODY) and Type 2 is that Type 1 is an auto-immune disease where your body treats your beta cells in the pancreas as a foreign invader, a disease, and kills the beta cells off so you can't produce insulin. With T2 they get over worked producing too much insulin and just get worn out.</p></blockquote><p></p>
[QUOTE="LittleGreyCat, post: 1625905, member: 6467"] I will try and tread very carefully here. Gliclazide works by over stimulating your pancreas to produce insulin. As they say in Blade Runner "The light that burns twice as bright burns half as long." So I think they are correct that in the long term your insulin production will decrease as your pancreas wears out. What I don't understand is why there is any need to switch off Metformin if you were achieving good control using that. Purely from my personal perspective, if I could manage just on Metformin I would be very reluctant to progress to Gliclazide. I regard that as the beginning of the slippery slope you describe above. You say "My BG has been perfect recently but with MODY the doctors say the best treatment is gliclazide.". It is probably worth checking around to see if this is the only route available to you. [URL]http://www.diabetes.co.uk/diabetes_mody.html[/URL] says that the most common type is due to the slow failure of your pancreas to produce enough insulin. If that has happened then Gliclazide is a logical step on the treatment path. How were you diagnosed with MODY? Why did they even test? You can tell I am having some mental indigestion over this. Anyway, welcome to the forum. You say "I'm not sure how t2 works to be honest ". Plenty of information on this site. Get stuck in and enjoy yourself :) Briefly, with T2 you are either producing enough insulin but your body is refusing to use it properly (Insulin Resistance) or your body isn't producing enough insulin (similar to MODY). I think the difference between Type 1 (which I understand includes MODY) and Type 2 is that Type 1 is an auto-immune disease where your body treats your beta cells in the pancreas as a foreign invader, a disease, and kills the beta cells off so you can't produce insulin. With T2 they get over worked producing too much insulin and just get worn out. [/QUOTE]
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