Hi, sorry forgot to say, i have had tests done, to see if it was the type of needles or preservatives in insulin, but it is actually the insulin molecule itself. i get what almost looks like a bee sting at the site that spreads for 24hours. they are hot to touch and very swollen. i have trouble controlling my sugars and change insulin every 2-4 weeks to try and keep the reactions down. I have tried antihistamines, immunosupresents, have been on the pump, tried various creams and skin washes but all not helped. any ideas?