Insulin & Insulin Resistance?

[kumar]

Hello,
Greetings!!

I want to know more about Lantus Insulin.

1.What is the purpose of keeping it at low pH 4? If it become hexamer at physiological pH, why it can't be supplied at physiological pH? Can't such low pH harm to injection sites because these sites may not be habitual to low pH?

2. Whether this insulin is released continually in blood from injection site after injected? How it happen?

Best wishes.

 

[kumar]

The process of downregulation occurs when there are elevated levels of the hormone insulin in the blood."
http://en.wikipedia.org/wiki/Downregulation_and_upregulation

"The oscillations are believed to be important for insulin sensitivity by preventing downregulation of insulin receptors in target cells."
http://en.wikipedia.org/wiki/Insulin_oscillations

I am quoting above links which we can be relavent.

 

[phoenix]

This is how the manufacturers explain it.
[url=http://www.lantus.com/m/hcp/how/default.aspx]http://www.lantus.com/m/hcp/how/default.aspx[/url]

 

[kumar]

Thanks. From the link provided by you;-

... The activity of LANTUS® results in a relatively constant concentration/time profile over 24 hours with no pronounced peak... Long-acting LANTUS® provides a continuous level of insulin, mimicking the slow, steady (basal) secretion of insulin provided by the normal pancreas. .
http://www.lantus.com/m/hcp/how/default.aspx

In this consideration, can't this continuous exposure interfere in Insulin Oscillations resuting downregulation & insulin resistance(refer links provided by me in my 2nd post)?

 

[kumar]

The process of downregulation occurs when there are elevated levels of the hormone insulin in the blood."
http://en.wikipedia.org/wiki/Downregulation_and_upregulation

"The oscillations are believed to be important for insulin sensitivity by preventing downregulation of insulin receptors in target cells."
http://en.wikipedia.org/wiki/Insulin_oscillations

Probably, we may have to look enhanced & continual insulin exposures by irregular food, oral medicines & exogenous(injected) insulin esp. long acting, also with above quoted terms.