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Mitochondrial disease and Type1A
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<blockquote data-quote="CeeJ" data-source="post: 625254" data-attributes="member: 125783"><p>Christine, </p><p></p><p>Do you know where the mutation is that is causing your MIDD? I've just found out today that I have the A3243G mutation. Apparently it is one of the more common mutations that cause mito disorders and can have a huge range if symptoms. </p><p></p><p>With regard to your experience of having to use large amounts of insulin since stopping metformin. I have read some articles in scientific journals that have said that generally mito disorder causes a reduction in insulin secretion, hence the dependence on insulin. However in rare cases there can also be increased insulin resistance (not sure what causes this). It might be worth mentioning this to your consultant to see if it's worth trying something other than meformin that will increase your sensitivity to insulin. It's just a thought and I have no medical training but you've got nothing to lose by suggesting it to your consultant. </p><p></p><p>Chris</p></blockquote><p></p>
[QUOTE="CeeJ, post: 625254, member: 125783"] Christine, Do you know where the mutation is that is causing your MIDD? I've just found out today that I have the A3243G mutation. Apparently it is one of the more common mutations that cause mito disorders and can have a huge range if symptoms. With regard to your experience of having to use large amounts of insulin since stopping metformin. I have read some articles in scientific journals that have said that generally mito disorder causes a reduction in insulin secretion, hence the dependence on insulin. However in rare cases there can also be increased insulin resistance (not sure what causes this). It might be worth mentioning this to your consultant to see if it's worth trying something other than meformin that will increase your sensitivity to insulin. It's just a thought and I have no medical training but you've got nothing to lose by suggesting it to your consultant. Chris [/QUOTE]
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