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Type 1.5/LADA Diabetes
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<blockquote data-quote="phoenix" data-source="post: 709072" data-attributes="member: 12578"><p>Re functioning well at lower levels ,something that came up elsewhere and something I know I noticed in the past and I'm not a low carber . In non diabetics there are a whole series of events which serve to warn and prevent of damaging hypoglycaemia . |For many of us the levels at which we perceive these symptoms is lower than that of non insulin taking people.</p><p>This article says that ,a current hypothesis is that people who have frequent hypos do indeed use alternative energy sources.(increased cerebral sources of glucose, ketones and lactate have all been suggested)</p><p> For example; People with diabetes and hypo unawareness have been found to have higher levels of lactate which the brain can use as a source of fuel. Lab animals also show adaptations of glucose transport during hypoglycaemia.</p><p>Brain adaptions/altered fuel, may indeed be what allows us to perceive better cognitive function at low levels and helps to prevent neuronal death.</p><p>The authors suggest that this is good in that cognition/brain function may be preserved during severe hypoglycaemia but </p><p>'Unfortunately, metabolic adaptations in patients with hypoglycemia unawareness that allow cognitive function at dangerously low blood sugar levels do so at the perilous risk of a precipitous hypoglycemic coma. Since limiting the awareness and symptoms of hypoglycemia jeopardizes patient safety, it must be considered a maladaptive response'</p></blockquote><p></p>
[QUOTE="phoenix, post: 709072, member: 12578"] Re functioning well at lower levels ,something that came up elsewhere and something I know I noticed in the past and I'm not a low carber . In non diabetics there are a whole series of events which serve to warn and prevent of damaging hypoglycaemia . |For many of us the levels at which we perceive these symptoms is lower than that of non insulin taking people. This article says that ,a current hypothesis is that people who have frequent hypos do indeed use alternative energy sources.(increased cerebral sources of glucose, ketones and lactate have all been suggested) For example; People with diabetes and hypo unawareness have been found to have higher levels of lactate which the brain can use as a source of fuel. Lab animals also show adaptations of glucose transport during hypoglycaemia. Brain adaptions/altered fuel, may indeed be what allows us to perceive better cognitive function at low levels and helps to prevent neuronal death. The authors suggest that this is good in that cognition/brain function may be preserved during severe hypoglycaemia but 'Unfortunately, metabolic adaptations in patients with hypoglycemia unawareness that allow cognitive function at dangerously low blood sugar levels do so at the perilous risk of a precipitous hypoglycemic coma. Since limiting the awareness and symptoms of hypoglycemia jeopardizes patient safety, it must be considered a maladaptive response' [/QUOTE]
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