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<blockquote data-quote="graj0" data-source="post: 674232"><p>I'm not a geneticist although my wife knows a fair bit and she tells me that although genes do not just appear, they do mutate, so who knows how long the gene has been around? To make things even more interesting that same gene will behave differently even in siblings, it needs something to switch it on (google epigenetics) and even then, as you say, it's not a forgone conclusion, just a predisposition to exhibit whatever the gene is supposed to be responsible for. So, it would be very useful to know that you have a predisposition to something because of genes, you might start avoiding action much younger, assuming you know that you have that gene and it's switched on.</p><p>I don't think anybody would suggest that life style is blameless, what I dislike is that because lifestyle can lead to diabetes, the NHS tells us that all diabetics need to look at their lifestyle, it's unfair to lump us all together, we're different.</p><p>For myself, I will say that with one skinny father, one average sized aunty (father's side), one chunky uncle (mum's side) all with type II, there seems to be a mixture of weight sizes with one thing in common, type II diabetes.</p><p>As for proportion of the diabetic community, who's got the numbers, we need to exclude type IIs with a wobbly pancreas not producing enough insulin and how many type IIs have had a c-peptide test? Then we need to look at the weight of each of the type IIs that we're left with, we could have small, medium and large and then with the larger ones we'd have to look at their lifestyle, or to be brutal, what they eat and drink. We shouldn't second guess the results, it would be interesting, perhaps somebody has already done the research.</p></blockquote><p></p>
[QUOTE="graj0, post: 674232"] I'm not a geneticist although my wife knows a fair bit and she tells me that although genes do not just appear, they do mutate, so who knows how long the gene has been around? To make things even more interesting that same gene will behave differently even in siblings, it needs something to switch it on (google epigenetics) and even then, as you say, it's not a forgone conclusion, just a predisposition to exhibit whatever the gene is supposed to be responsible for. So, it would be very useful to know that you have a predisposition to something because of genes, you might start avoiding action much younger, assuming you know that you have that gene and it's switched on. I don't think anybody would suggest that life style is blameless, what I dislike is that because lifestyle can lead to diabetes, the NHS tells us that all diabetics need to look at their lifestyle, it's unfair to lump us all together, we're different. For myself, I will say that with one skinny father, one average sized aunty (father's side), one chunky uncle (mum's side) all with type II, there seems to be a mixture of weight sizes with one thing in common, type II diabetes. As for proportion of the diabetic community, who's got the numbers, we need to exclude type IIs with a wobbly pancreas not producing enough insulin and how many type IIs have had a c-peptide test? Then we need to look at the weight of each of the type IIs that we're left with, we could have small, medium and large and then with the larger ones we'd have to look at their lifestyle, or to be brutal, what they eat and drink. We shouldn't second guess the results, it would be interesting, perhaps somebody has already done the research. [/QUOTE]
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