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Can you help me write my journal article or ad?

Do you have the "hunter" (thrifty) gene?


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    4
  • Poll closed .

yetta2mymom

Well-Known Member
Messages
337
Location
Winchester Massachusetts
Type of diabetes
Don't have diabetes
Treatment type
Diet only
Dislikes
?
I have been using you (my appoligies if necessary) to figure out a major contribution (my opinion) about the way humans process sugar. Any comments, corrections etc... for the following journal article (sort of accepted but I will believe it when I see it) would be appreciated. Please do not be disturbed if it takes my brain days to process any such comment, critisim , you are wrong etc...

Here is the latest version of my journal article.



This is an explanation of why I had such disturbing symptoms for about 50 years until I figured out that a very low sugar/starch diet seemed to be relieving my symptoms. It then took approximately an additional 2 years for almost all my symptoms to clear. It then took about 6 years and a lot of serendipity to figure out what was the problem. I am sorry that this explanation is long but I have been told it is complicated. It is a fact that about ½ the women in India have my gene and it leads to all the sugar problems in pregnancy. Considering my gene leads to a diagnosis of prediabetic that is what ex Indians told me. I quote from one nurse who said about the sugar problems in pregnancy “it must be genetic”.

I wish to help fund a study that follows the glucose tolerance tests (GTT, see footnotes 1 and 2) of women before, during and after pregnancy.

A major reason for this study is that a doctor on PBS in 2015 drew two graphs of a GTT. GTT’s run for 2 hours. The first GTT went up and then down. He indicated this is the expected GTT. The second GTT slowed its rate of assent but was still rising as he lifted his marker. The second is my GTT (2) taken in 1964. Does anyone know the name of this doctor? He defined such people as having a “hunter” gene. He said people with this GTT did not lose weight on his weight loss diet. The diabetic community says this sounds like the “thrifty” gene. Since people with the “hunter” gene should be better able to survive famines there must be a downside to this gene. I guess one downside is that women with this gene have problems controlling their blood sugar during pregnancy.

The following paragraph contains my actionable conclusions. Details describing them and what lead up to some of these conclusions follow.


In my wildest dreams this article would eventually lead to everyone getting a baseline glucose tolerance test (GTT), I strongly suggest you ask your physician to take a GTT to find out if you have the normal GTT or the “hunter” GTT. Another dream is that doctors would publicize that you can get an autoimmune disease if you have the “hunter” gene, if you have the “hunter” gene and become chronically fatigued I suggest you see if cutting back you’re sugar/starch improves how you feel. An even bigger dream is that a very low sugar/starch diet would be tried on all type 2 diabetics and it successfully controlled high blood sugar, for some diabetics this may be a better option then the standard treatment. In that case make sure you monitor your blood sugar to see if you have cut your sugar/starch enough. Another dream is that it would be found that people with the “hunter” gene tend to become fat on the modern diet, for me a low fat diet worked if you have the “hunter” gene see if this works for you. As the weight loss doctor said “people with the hunter gene do not lose weight on his weight loss diet”. This would then lead to the following obvious question. Is the hunter gene the reason for the weight problems, when they try the modern diet, with the Indian population, American Indians, Pacific Islanders etc.…? If so all my advice follows for these people. Since all humans probably have the ability to produce hormones which create insulin resistance maybe type 2 diabetes is these hormones gone amok. In that case a treatment which affects the hormones may be superior to all the present possibilities. After years on a severe very low sugar/starch diet my high blood pressure corrected itself without medication. Is the amount of insulin produced by our diet the fundamental reason for most high blood pressure? Could a low sugar/starch diet generally lead to a correction of high blood pressure?

An ex Indian told me approximately ½ the people of India are diagnosed as prediabetic (1). This indicates why. I also present a theory about an alternate method of sugar storage used by some humans. I have the following question, assume a women has sugar problems during pregnancy. How can you see if her GTT has returned to normal after pregnancy if you don’t know what is her normal GTT? I have the following observation if women with the “hunter” gene are much more susceptible to sugar problems during pregnancy maybe you can explore possible pre pregnancy interventions with these women.

In 1964 a doctor looked at my GTT and said I was prediabetic (1) and was developing insulin resistance. I am fat and have done all the wrong things but I am not a diabetic. The reason for my GTT in 1964 is that I get low blood sugar many hours after eating too much sugar/starch/alcohol (S). I know of 4 other people with the hunter gene who also have this symptom. We also have other symptoms starting with much lower values of S. The symptoms are some degree of brain fog and fatigue. These symptoms are controlled by never letting our blood sugar go above an unknown value.

I theorize that the hunter gene allows people to only store sugar when their blood sugar rises above some value (3). Consider the following. Evolutionary changes are often additions to existing processes. Women with the “hunter” gene have insulin resistance in pregnancy. Insulin is needed to process protein. Look at my glucose tolerance test (2). I am lead to the following weird conclusion. With the “hunter” gene people are normally in a state of insulin resistance. They are usually simulating type 2 diabetes. When their body determines that the blood sugar is heading for dangerous territory, that is, it will affect the general chemistry of the blood, the body cuts insulin resistance and generates insulin so that the excess blood sugar is changed into fat. My wild guess is that the “hunter” or “thrifty” gene people are constantly producing hormones to create insulin resistance (7). When the blood sugar gets too large they stop producing these hormones and maybe start producing a little insulin. After a time gap to allow the hormones to clear they produce a large enough quantity of insulin to make most of the sugar in their blood become fat. Then, I guess with lower confidence, when their blood sugar gets low enough to possibly lead to hypoglycemia they restart their hormones. I further speculate that people with the “normal” sugar processing also use these hormones for a short time when hypoglycemia threatens. I think that people with one of the reactive hypoglycemia symptoms have disabled this response.

I am on a very low sugar/starch diet. I am simulating a type 2 diabetic almost all the time. I speculate this was true for the hunters from which I arose.

I have reason to believe I had an episode which was an autoimmune reaction (4). I therefore theorize that doctors should be aware that it is possible for people with the hunter gene to have one type cell of their adrenal glands destroyed which compromises the possibly complicated chemistry that allows them to store sugar based on their blood sugar. Doctors should advise people with the reactive hypoglycemia and GTT I have described that they will feel better if they carefully control the S in their diet (5). I only know of 5 people with the autoimmune problem I describe and only two have had their symptoms diagnosed by doctors. The doctors noted that diet controlled their problem but had no idea what was happening. I therefore suggest that doctors make people with the hunter gene aware of this possibility.

My diet is low enough in sugar/starch that with my hunter gene I have turned off the effects of insulin. My evidence is that my fasting blood sugar has risen, but is very normal, because I never lower it with insulin (6). Further on occasion I have gained weight on this diet. I comment that years ago I was able to lose about 80 pounds in approximately 1 year on a crash diet of pasta with cottage cheese with enough vegetables for vitamins. I also comment that I am presently losing weight on my very low sugar/starch diet by cutting out almost all cheese. Since my meat portions are comparatively small I assume I am losing weight for the standard reason. Further I have no discernible problem with exercise even with my extreme diet with very low sugar/starch. My fasting blood sugar has stabilized at near the highest but normal values, ever (6). Have I returned to my hunter roots?

(1) Defined as too high a blood glucose reading 2 hours after ingesting sugar after a fast.

(2) GTT 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100.

(3) I have read that up to 1/3 of the energy in sugar is used up in storing and later releasing the sugar.

(4) During 1957 in approximately 2 months I lost approximately 20-25 pounds developed an overactive bladder and started my fatigue symptom.

(5) I eat a very low sugar/starch diet. Another patient posts he/she feels fine with a diet which includes slowly absorbing starch.

(6) Latest: Fasting blood sugar 98 A1C 5.5

(7) Dr Vaidya pointed out that the body produces HPL in pregnancy which creates insulin resistance. This could be the hormone used to create insulin resistance in the “hunter” gene population. Judging by my GTT the body probably stops the (HPL?) when the blood sugar gets to approximately 170. The time lag before it then tries to mop up the sugar in the blood seems to be over 1 hour.
 
What's an ex Indian?
Hi
Some one who migrated from India is what I call an ex Indian
another way of putting the hunter thrifty gene is to call it the saver prudent gene

wonder about nurture nature with this propensity

had genetic testing?
another way of putting the hunter thrifty gene is to call it the saver prudent gene

wonder about nurture nature with this propensity

had genetic testing?
Hi
Someone who I (thought) migrated from India. I interviewed people and asked where they came from and/or are you an Indian? I originally was sure I had adrenal hypoplasia since many Jews do. I checked for all the know genes for this condition and came back negative. Dr A
another way of putting the hunter thrifty gene is to call it the saver prudent gene

wonder about nurture nature with this propensity

had genetic testing?

I interviewed people and asked where do you come from and/or are you from Indian. There seems to be a (large?) group of ex Indians in the Boston Area.. I originally was sure I had adrenal hypoplasia as many Jews have that genetic problem. Dr. V. indicates that they just do not know a lot about the specifics of the adrenal glands.
 
I gain about 5 to 10 pounds a year if I eat the normal diet which would not lead to weight gain for the "normal?" gene people. I am now losing weight, have lost about 20-25 pounds from when I cut out cheese about 8 months ago. I eat a very low sugar/starch diet with a naked salad with no high starch vegetables and/or high sugar/starch prepared salads mixed in to the salad . I eat a lot of small portions of meat attempting to remove most of the fat. My treat is pure coca (from backing goods). Tastes fine to me. I can detect a small amount of sugar in anything (I do get false alarms).
 
Surely wherever they live their ethnicity is still Indian - my family come from all over the world and have moved countries many times - how does their ethnicity change? Not being awkward just not really understanding
 
Hi

I have the gene and I am from European Jewish stock. It seems people who stayed in India for many generations ended up with this gene by natural selection as India was subject to repeated famines as the monsoons failed.
Neil
 
We watched a science / reality programme on SBS television here a month or so ago, that showed some people have a touch of the neanderthal gene in their dna.

It depends where you come from I suppose, but I feel a bit primitive at times.
 
Wasn't there a thread a couple of mouths ago from you about this same topic? If I remember correctly it was closed.
We watched a science / reality programme on SBS television here a month or so ago, that showed some people have a touch of the neanderthal gene in their dna.

It depends where you come from I suppose, but I feel a bit primitive at times.
All my family is from Switzerland. Perhaps that's why I can eat chocolate with out it rising my BS too much;)
 
Hi

I had political problems on your site and any thing I posted was quickly closed. I wrote letters to all the doctors, a professor and a nurse who are on the board of this site and told my contact I got when I complained that I had done that (after giving more than a week for my political problems to go away). I am now back.
I eat a lot of straight coca that has some sugar but not enough to rise my blood sugar to the point where my body goes into save sugar mode and I have problems due to my auto immune problem (if you want a guess my blood sugar goes low pretty quickly but not low enough to lead to major problems).
My last guess is that the 2 forms of processing sugar have been around a very long time and natural selection has made one or the other predominant when conditions favored one or the other. If an isolated population had only one form of processing then a stranger with the other form would interbred or there was conquests etc...
 
I have the gene

What gene? Is this a gene that has actually been identified and mapped? Is it a gene that you have had a positive DNA test for?

If not, you can't possibly say you have the gene, all you have is an unfounded idea based upon a misunderstanding of what type 2 is (a portfolio condition) and what gestational diabetes is (a temporary condition that resolves following birth but leaves an increased risk of developing type 2 - you also appear to not understand the concept of risk).
 
Hi

I do not know what the gene is but since people with my type of sugar processing can interbreed with people with the normal sugar processing it is unlikely that there is more difference in our genetics than 1 or at most a few genes. A good research (very difficult) project would be to identify the gene. With the modern technology and the fact that you should be able to find (Indians, American Indians etc...) with the my method of processing sugar you may be able to tease out the difference between the 2 types of processing sugar.
 
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Hi

Taking me down if you disagree is a political act. Actually for some cases that would be right. I just thought that in my case I am looking for information. Disgreeing is not. I miswrote I never actually emailed this with Dr V. I took out that overstatement. Believe it or not I process all comments and often days later I have either a favorable or not completely unfavorable (word?). The reason why I put my conclusions early in this ad was that Dr V. thought it was too long. The fact that insulin is necessary for proper digestion of protein clinched(for me) the simulate type 2 arguement. I have downplayed but I think it is very likely most (all?) type 2 diabetes is the hormones not stopping. After all I am living with the hormones always on.
 
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I actually think that you have an interesting concept here. However, it's a very difficult train of thought to follow because you go off topic pretty frequently in your posts.

I say this constructively, but I think you'd get a much better response if you could make your thoughts a bit more concise and objective.

Again, it's an interesting theory. Just a little too much fluff at the moment.
 
Hi

I attempt to answer all enquires. Each one is different. A particular case of fluff would possibly help. I am aware that I am much better at deriving consepts then expressing same. One (sub?) reason for this post is an attempt to learn how (even with my advanced age). Actually any such fluff in the proposed ad would be even more helpful. I tried in my ad to overcome the problems noted but I answer comments as they come in. Note I see reasons why some posts should be taken down. You want everyone to have a chance.
 
Have you seen those adverts for DNA testing kits? You could trace your ancestral genes through them and know where your genes came from. This might give more credibility to your theory.
 
I have been using you (my appoligies if necessary) to figure out a major contribution (my opinion) about the way humans process sugar. Any comments, corrections etc... for the following journal article (sort of accepted but I will believe it when I see it) would be appreciated. Please do not be disturbed if it takes my brain days to process any such comment, critisim , you are wrong etc...
Here is the latest version of my journal article.
This is an explanation of why I had such disturbing symptoms for about 50 years until I figured out that a very low sugar/starch diet seemed to be relieving my symptoms. It then took approximately an additional 2 years for almost all my symptoms to clear. It then took about 6 years and a lot of serendipity to figure out what was the problem. I am sorry that this explanation is long but I have been told it is complicated. It is a fact that about ½ the women in India have my gene and it leads to all the sugar problems in pregnancy. Considering my gene leads to a diagnosis of prediabetic that is what ex Indians told me. I quote from one nurse who said about the sugar problems in pregnancy “it must be genetic”.
Since you asked for specific feedback, here's some constructive criticism about the first two paragraphs you wrote:

-“I have been using you...” Leave these personal disclaimers out completely. Instead, explain your objectives for this thread and move on.
-A “Very low sugar/starch diet” relieved your symptoms? How low (in calories or grams) and what were your specific symptoms?
-Words like “Serendipity” should be absent from any legitimate health article.
-You apologize again for making the explanation long. Ironically, that only makes it longer and serves no other purpose.
-It is a fact that ½ women in India have this gene? Cite your source to prove that fact
-What is an “Ex Indian?” My fiancé is from India and moved here to the USA when she was 2. I’ve never once heard anyone use that term.
-You quoted “One nurse” and used an arbitrary quote that explains nothing and offers zero insight. “It must be genetic” offers no value towards your point, and that’s especially true if you can’t be more specific about who said it.
 
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