The best time to take Metformin, is just before or with food to avoid acid reflux indigestion, that this medication can cause, as well as anti inflammatory pills.
[QUOTE="Annie B, post
The reason you are advised to take Metformin just before or wirh food, is to avoid acid indigestion. The same as with certain pain killers and anti inflammatory tablets. They cause bad acid reflux on an empty stomach. Hope that helps.